Component
Plasma and muscle histidine during controlled depletion
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Histidine-deficient feeding reduced plasma histidine by 82 +/- 6 percent and muscle histidine by 62 +/- 19 percent; both rose with repletion.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Controlled sequential metabolic-unit feeding in four healthy and three chronically uremic men; histidine-deficient amino-acid diet for 35 +/- 2 days, followed by histidine-containing diet for 31 +/- 5 days.
- limitations
- Small historical nonrandomized sequential study; mixed renal status and artificial diet. Does not define a universal plasma cutoff, ordinary dietary prevalence or replacement dose.
- nutrient_topic
- L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Histidine
- plain_language
- Blood and muscle pools both fell, but by different amounts.
- primary_references
- Evidence that histidine is an essential amino acid in normal and chronically uremic man. · 1975 · https://pubmed.ncbi.nlm.nih.gov/1123426/ · DOI 10.1172/JCI108016
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19) · lines 34–40
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Controlled sequential metabolic-unit feeding in four healthy and three chronically uremic men; histidine-deficient amino-acid diet for 35 +/- 2 days, followed by histidine-containing diet for 31 +/- 5 days. · source_derived_draft · unverified_draft
## histidine-diet-pools Blood and muscle pools both fell, but by different amounts. Histidine-deficient feeding reduced plasma histidine by 82 +/- 6 percent and muscle histidine by 62 +/- 19 percent; both rose with repletion. Model: Controlled sequential metabolic-unit feeding in four healthy and three chronically uremic men; histidine-deficient amino-acid diet for 35 +/- 2 days, followed by histidine-containing diet for 31 +/- 5 days. Limitations: Small historical nonrandomized sequential study; mixed renal status and artificial diet. Does not define a universal plasma cutoff, ordinary dietary prevalence or replacement dose. Evidence access: Primary abstract Evidence that histidine is an essential amino acid in normal and chronically uremic man. · 1975 · https://pubmed.ncbi.nlm.nih.gov/1123426/ · DOI 10.1172/JCI108016
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.