Component
Human hepatocyte growth factor / HGF
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
SA increased the HGF transcript readout in human dermal papilla cells.
Experimental context and source evidence
- evidence_access
- Primary full text retrieved; relevant methods/results/figures reviewed. Selective extraction, not raw-data reanalysis or exhaustive supplemental extraction.
- experimental_contrast
- {"intervention": "SA", "comparator": "Vehicle", "endpoint": "SA increased the HGF transcript readout in human dermal papilla cells.", "effect_direction": "increase", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Human dermal papilla cells; 1 µM SA for 24 h, qPCR.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Transcript level is not measured secretion, target binding or clinical hair growth.
- plain_language
- SA increased the HGF transcript readout in human dermal papilla cells.
- primary_references
- Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle. | 2019 | DOI 10.1038/s41598-019-53612-5 | PMID 31740717 | https://pubmed.ncbi.nlm.nih.gov/31740717/ | https://doi.org/10.1038/s41598-019-53612-5 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6861222/
- source_locator
- Reviewed reference lines 75-75; exact primary location described in quoted passage where extracted.
Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 75–75
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Human dermal papilla cells; 1 µM SA for 24 h, qPCR. · source_derived_draft · unverified_draft
**Hair-follicle findings include human tissue, not a human treatment trial.** In isolated human hair follicles, 1 or 10 µM shikimic acid increased shaft elongation during 12-day culture. Dermal papilla cells showed higher MTT readouts, and 1 µM exposure increased MYC, HGF, KGF and VEGF transcripts at 24 h and p38/CREB phosphorylation at 15 min. Transcript increases are not proof of increased secreted growth-factor flux. Mannose-receptor staining establishes receptor presence, not that this receptor was necessary for the response. Topical 10–100 mM exposure also affected anagen-related measurements in mice; neither system establishes oral human hair regrowth. [Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle.](https://pubmed.ncbi.nlm.nih.gov/31740717/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.