Component
Human fecal menaquinone association with glycemia, insulin resistance and inflammation
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Longitudinal fecal menaquinone patterns did not associate significantly with glycemia, insulin resistance or inflammatory markers in the recorded cohort.
Experimental context and source evidence
- evidence_access
- Primary indexed abstract reviewed; full results, tables and supplements not independently extracted.
- experimental_model
- 77 overweight Chinese adults during a diet intervention.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Observational association null; not proof of absence of every vitamin-K effect or absorbed exposure.
- plain_language
- Longitudinal fecal menaquinone patterns did not associate significantly with glycemia, insulin resistance or inflammatory markers in the recorded cohort.
- primary_references
- Fecal menaquinone profiles of overweight adults are associated with gut microbiota composition during a gut microbiota-targeted dietary intervention. | 2015 | DOI 10.3945/ajcn.115.109496 | PMID 26016865 | https://pubmed.ncbi.nlm.nih.gov/26016865/ | https://doi.org/10.3945/ajcn.115.109496
- primary_references
- Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme. | 2010 | DOI 10.1038/nature09464 | PMID 20953171 | https://pubmed.ncbi.nlm.nih.gov/20953171/ | https://doi.org/10.1038/nature09464
- source_locator
- Reviewed reference lines 31-31; exact primary location described in quoted passage where extracted.
Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 31–31
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 77 overweight Chinese adults during a diet intervention. · Recorded from source · Recorded from source
**Fecal vitamin K is not absorbed vitamin K.** In 77 overweight Chinese adults, fecal menaquinone patterns associated with microbial composition. A diet intervention decreased fecal MK-4, MK-6 and MK-8, but longitudinal menaquinone patterns did not associate with glycemia, insulin resistance or inflammation. Separately, human UBIAD1 silencing reduced MK-4 biosynthesis in labeled-precursor experiments; UBIAD1 is a host prenyltransferase, not a shikimate-pathway enzyme. Neither result proves that microbial shikimate output determines tissue vitamin-K adequacy. [Fecal menaquinone profiles of overweight adults are associated with gut microbiota composition during a gut microbiota-targeted dietary intervention.](https://pubmed.ncbi.nlm.nih.gov/26016865/) [Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme.](https://pubmed.ncbi.nlm.nih.gov/20953171/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.