Component
Human dysthymia Hamilton depression score
Human dysthymia Hamilton depression score
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The ALCAR–amisulpride trial did not meet its prespecified two-point noninferiority margin.
Experimental context and source evidence
- evidence_access
- Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
- experimental_contrast
- {"intervention": "ALCAR regimen", "comparator": "Amisulpride regimen", "endpoint": "The ALCAR–amisulpride trial did not meet its prespecified two-point noninferiority margin.", "effect_direction": "mixed", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- 204 randomized; ALCAR 500 mg twice daily versus amisulpride 50 mg/day for 12 weeks.
- interpretation_status
- Source-derived curation with stated access limits; ungraded, not independent replication.
- limitations
- Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
- nutrient_topic
- Acetyl-L-carnitine collection; exact intervention and molecular form govern interpretation. · Acetyl-L-carnitine
- plain_language
- The ALCAR–amisulpride trial did not meet its prespecified two-point noninferiority margin.
- primary_references
- A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia. | https://pubmed.ncbi.nlm.nih.gov/16316746/ | https://doi.org/10.1016/j.euroneuro.2005.10.005
- source_locator
- Reviewed reference dysthymia-noninferiority; The confidence interval exceeded the prespecified margin by 0.46 points. A wider three-point margin discussed afterward does not replace the original test. Both arms improved; nonsignificant superiority does not prove equivalence.
Acetyl-L-carnitine: detailed mechanisms of action (reviewed 6 October 2026) · lines 587–593
AI-assisted original review of primary studies and clearly identified official records. Exact primary access is stated; no independent replication is claimed. · supports · 204 randomized; ALCAR 500 mg twice daily versus amisulpride 50 mg/day for 12 weeks. · Recorded from source · Recorded from source
### dysthymia-noninferiority The ALCAR–amisulpride trial did not meet its prespecified two-point noninferiority margin. The confidence interval exceeded the prespecified margin by 0.46 points. A wider three-point margin discussed afterward does not replace the original test. Both arms improved; nonsignificant superiority does not prove equivalence. Model and exposure: 204 randomized; ALCAR 500 mg twice daily versus amisulpride 50 mg/day for 12 weeks. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia. | 2006 | https://pubmed.ncbi.nlm.nih.gov/16316746/ | https://doi.org/10.1016/j.euroneuro.2005.10.005 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.