Component
Human microsomal curcumin-glucuronidating UGT activities, isoforms unresolved in the 2002 study
Human microsomal curcumin-glucuronidating UGT activities, isoforms unresolved in the 2002 study. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Curcumin glucuronide was identified after incubation with human intestinal and hepatic microsomes.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/curcumin-research/11815407.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8", "start_char": 0, "end_char": 2113, "text_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8"}
- experimental_model
- Human and rat tissue fractions and enzyme assays
- exposure
- Curcumin incubated with tissue fractions or purified sulfotransferases
- limitations
- Ex-vivo metabolism does not measure whole-person bioavailability. Isoforms are specified only where experimentally identified.
- nutrient_topic
- Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
- organism
- Human assays below; rat experiments not merged
- plain_language
- The gut and liver can attach glucuronide to curcumin.
- primary_references
- [curcumin-p11815407] Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. (2002). https://pubmed.ncbi.nlm.nih.gov/11815407/
- tissue_or_cell_type
- Intestinal and hepatic microsomes and cytosol
Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 138–149
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human and rat tissue fractions and enzyme assays · source_derived_draft · unverified_draft
### curcumin-glucuronide Curcumin glucuronide was identified after incubation with human intestinal and hepatic microsomes. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The gut and liver can attach glucuronide to curcumin. organism: Human assays below; rat experiments not merged tissue_or_cell_type: Intestinal and hepatic microsomes and cytosol experimental_model: Human and rat tissue fractions and enzyme assays limitations: Ex-vivo metabolism does not measure whole-person bioavailability. Isoforms are specified only where experimentally identified. exposure: Curcumin incubated with tissue fractions or purified sulfotransferases evidence_span: {"source_cache": "artifacts/curcumin-research/11815407.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8", "start_char": 0, "end_char": 2113, "text_sha256": "028fbc6d7e7e728f7e52970df07c8e9b04053abe4799669798d593369d2c23b8"} [curcumin-p11815407] Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. (2002). https://pubmed.ncbi.nlm.nih.gov/11815407/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.