Component
Gas, cramps and bloating in children with congenital sucrase-isomaltase deficiency
Species, exposure, manipulation and limitations are specified on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Higher sacrosidase concentrations reduced gas, cramps and bloating during carbohydrate-containing diets in children with CSID.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- dose
- Yeast sucrase preparation, 6000 IU/mg protein; full strength and 1:10, 1:100, 1:1000 dilutions; >15 kg received 2 mL; lower-weight dose volume missing from accessed abstract
- duration
- Single-dose breath tests; four 10-day dose periods
- evidence_access
- Primary abstract/metadata; unrecovered methods explicitly retained.
- evidence_scope
- literature_reviewed; source-specific curation
- experimental_model
- 28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial
- exposure_scope
- Drug rescue of human genetic digestive impairment
- limitations
- Enzyme replacement in diagnosed CSID, not sucrose supplementation for a nutrient deficiency. Exact sucrose challenge amount and lower-weight volume unrecovered. Vomiting did not differ; wheezing occurred in one child with asthma. Not prescribing guidance.
- nutrient_topic
- Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
- organism
- 28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial
- plain_language
- Higher sacrosidase concentrations reduced gas, cramps and bloating during carbohydrate-containing diets in children with CSID.
- primary_references
- Sacrosidase therapy for congenital sucrase-isomaltase deficiency. (1999). https://pubmed.ncbi.nlm.nih.gov/9932843/ DOI: 10.1097/00005176-199902000-00008
- route
- Oral enzyme with sucrose challenge or normal carbohydrate-containing diet
- tissue
- Intestinal sucrose handling and stool/symptom outcomes
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 187–197
Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · 28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial · source_derived_draft · unverified_draft
## sucrose-sacrosidase-symptoms Higher sacrosidase concentrations reduced gas, cramps and bloating during carbohydrate-containing diets in children with CSID. Model/species: 28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial Tissue: Intestinal sucrose handling and stool/symptom outcomes Exposure: Yeast sucrase preparation, 6000 IU/mg protein; full strength and 1:10, 1:100, 1:1000 dilutions; >15 kg received 2 mL; lower-weight dose volume missing from accessed abstract Route: Oral enzyme with sucrose challenge or normal carbohydrate-containing diet Duration: Single-dose breath tests; four 10-day dose periods Exposure scope: Drug rescue of human genetic digestive impairment Limits: Enzyme replacement in diagnosed CSID, not sucrose supplementation for a nutrient deficiency. Exact sucrose challenge amount and lower-weight volume unrecovered. Vomiting did not differ; wheezing occurred in one child with asthma. Not prescribing guidance. Reference: Sacrosidase therapy for congenital sucrase-isomaltase deficiency. (1999). https://pubmed.ncbi.nlm.nih.gov/9932843/ DOI: 10.1097/00005176-199902000-00008 Access: Primary abstract/metadata; unrecovered methods explicitly retained.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.