Component
Human plasma appearance of cecally administered labeled folate
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Cecally supplied labeled folate appeared in plasma as labeled 5-methyltetrahydrofolate in six healthy adults.
Experimental context and source evidence
- evidence_access
- Primary full-text HTML and indexed abstract reviewed for the stated results; archived locally.
- experimental_model
- Cecal 684-nmol isotope administration; separate intravenous comparator.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Absorption of supplied folate, not measurement of daily microbial vitamin contribution or shikimate supplementation.
- plain_language
- Cecally supplied labeled folate appeared in plasma as labeled 5-methyltetrahydrofolate in six healthy adults.
- primary_references
- Folate is absorbed across the colon of adults: evidence from cecal infusion of (13)C-labeled [6S]-5-formyltetrahydrofolic acid. | 2009 | DOI 10.3945/ajcn.2008.27345 | PMID 19439459 | https://pubmed.ncbi.nlm.nih.gov/19439459/ | https://doi.org/10.3945/ajcn.2008.27345 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6443296/
- source_locator
- Reviewed reference lines 29-29; exact primary location described in quoted passage where extracted.
Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 29–29
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Cecal 684-nmol isotope administration; separate intravenous comparator. · Recorded from source · Recorded from source
**Production and absorption are separate questions.** A human stable-isotope study delivered 684 nmol (320 µg) of labeled [6S]-5-formyltetrahydrofolate to the cecum of six healthy adults. Labeled 5-methyltetrahydrofolate appeared in plasma; appearance was about 0.6 ± 0.2 nmol/h versus 7 ± 1.2 nmol/h after a separate 172-nmol intravenous administration. This demonstrates colonic absorption of a supplied folate preparation under the study conditions. It does not quantify habitual microbial folate contribution, prove a shikimate intervention, or establish equal absorption of every microbial folate form. [Folate is absorbed across the colon of adults: evidence from cecal infusion of (13)C-labeled [6S]-5-formyltetrahydrofolic acid.](https://pubmed.ncbi.nlm.nih.gov/19439459/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.