Component
Human cancer-cell H3K23/H4K8/H4K12 acetyl carbon
Human cancer-cell H3K23/H4K8/H4K12 acetyl carbon
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
ALCAR acetyl carbon was traced into H3K23ac, H4K8ac and H4K12ac in the 2026 cancer-cell study.
Experimental context and source evidence
- evidence_access
- Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
- experimental_model
- Stable-isotope tracing, Extended Data Fig. 8e; site-specific histone mass spectrometry.
- interpretation_status
- Source-derived curation with stated access limits; ungraded, not independent replication.
- limitations
- Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
- nutrient_topic
- Acetyl-L-carnitine collection; exact intervention and molecular form govern interpretation. · Acetyl-L-carnitine
- plain_language
- ALCAR acetyl carbon was traced into H3K23ac, H4K8ac and H4K12ac in the 2026 cancer-cell study.
- primary_references
- αKG-mediated carnitine synthesis drives DNA repair via histone acetylation. | https://pubmed.ncbi.nlm.nih.gov/42203879/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13307467/ | https://doi.org/10.1038/s41586-026-10584-7
- source_locator
- Reviewed reference cancer-histone-sites; These marks were sensitive to the alpha-ketoglutarate/TMLHE/carnitine axis. They are not the same promoter-specific H3K27 readout measured in the rat depression study.
Acetyl-L-carnitine: detailed mechanisms of action (reviewed 6 October 2026) · lines 320–326
AI-assisted original review of primary studies and clearly identified official records. Exact primary access is stated; no independent replication is claimed. · supports · Stable-isotope tracing, Extended Data Fig. 8e; site-specific histone mass spectrometry. · Recorded from source · Recorded from source
### cancer-histone-sites ALCAR acetyl carbon was traced into H3K23ac, H4K8ac and H4K12ac in the 2026 cancer-cell study. These marks were sensitive to the alpha-ketoglutarate/TMLHE/carnitine axis. They are not the same promoter-specific H3K27 readout measured in the rat depression study. Model and exposure: Stable-isotope tracing, Extended Data Fig. 8e; site-specific histone mass spectrometry. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: αKG-mediated carnitine synthesis drives DNA repair via histone acetylation. | 2026 | https://pubmed.ncbi.nlm.nih.gov/42203879/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13307467/ | https://doi.org/10.1038/s41586-026-10584-7 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.