Component
Estimated oral biotin bioavailability in humans
Estimated oral biotin bioavailability in humans. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Similar urinary recovery after the two larger oral biotin doses and the intravenous dose supported near-complete oral absorption in six healthy adults.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/biotin-research/10075337.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8eb8ff3bb786de29bfda6f596af2fe6e8fdf366d9cad84065176a825d6035ebd", "start_char": 0, "end_char": 1677, "text_sha256": "8eb8ff3bb786de29bfda6f596af2fe6e8fdf366d9cad84065176a825d6035ebd"}
- experimental_model
- Crossover oral and intravenous administration in 6 healthy adults
- exposure
- Oral 2.1, 8.2 or 81.9 micromol; intravenous 18.4 micromol biotin
- limitations
- Bioavailability was inferred from urinary recovery; the anomalous smallest dose and small healthy sample limit generalization to malabsorption or transporter disease.
- nutrient_topic
- Biotin research collection; topical membership is not evidence of a direct dietary effect. · Biotin
- organism
- Homo sapiens
- plain_language
- High oral doses were still well absorbed in this small study.
- primary_references
- [b7-p10075337] Bioavailability of biotin given orally to humans in pharmacologic doses. (1999). https://pubmed.ncbi.nlm.nih.gov/10075337/ DOI: 10.1093/ajcn/69.3.504
- tissue_or_cell_type
- Whole-body urinary recovery
Biotin: carboxylases, recycling, deficiency and nutrient interactions (2026-09-17) · lines 325–336
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Crossover oral and intravenous administration in 6 healthy adults · source_derived_draft · unverified_draft
### b7-oral-bioavailability Similar urinary recovery after the two larger oral biotin doses and the intravenous dose supported near-complete oral absorption in six healthy adults. Condition category: normal nutrient_topic: Biotin research collection; topical membership is not evidence of a direct dietary effect. plain_language: High oral doses were still well absorbed in this small study. organism: Homo sapiens tissue_or_cell_type: Whole-body urinary recovery experimental_model: Crossover oral and intravenous administration in 6 healthy adults limitations: Bioavailability was inferred from urinary recovery; the anomalous smallest dose and small healthy sample limit generalization to malabsorption or transporter disease. exposure: Oral 2.1, 8.2 or 81.9 micromol; intravenous 18.4 micromol biotin evidence_span: {"source_cache": "artifacts/biotin-research/10075337.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8eb8ff3bb786de29bfda6f596af2fe6e8fdf366d9cad84065176a825d6035ebd", "start_char": 0, "end_char": 1677, "text_sha256": "8eb8ff3bb786de29bfda6f596af2fe6e8fdf366d9cad84065176a825d6035ebd"} [b7-p10075337] Bioavailability of biotin given orally to humans in pharmacologic doses. (1999). https://pubmed.ncbi.nlm.nih.gov/10075337/ DOI: 10.1093/ajcn/69.3.504
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.