Component
Airway response to tartrazine in aspirin-intolerant asthmatics
Experimental model, exposure and limitations remain on each linked record.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Four of 156 aspirin-intolerant asthmatics had a double-blind-confirmed tartrazine response with more than a 25% FEV1 fall and symptoms.
Experimental context and source evidence
- dose
- Increasing tartrazine doses up to 25 mg; positive open challenges repeated double blind
- duration
- Acute challenge; exact observation window not specified in abstract
- evidence_access
- Primary PubMed abstract; unrecovered method details explicitly retained.
- evidence_scope
- literature_reviewed; source-specific experimental curation
- experimental_model
- 156 patients with confirmed aspirin-induced asthma in a multicenter study
- limitations
- Four confirmed reactions do not establish universal aspirin-tartrazine cross-reactivity or a shared IgE/COX mechanism. Results are specific to the recruited population.
- nutrient_topic
- Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits. · Tartrazine
- organism
- 156 patients with confirmed aspirin-induced asthma in a multicenter study
- plain_language
- Four of 156 aspirin-intolerant asthmatics had a double-blind-confirmed tartrazine response with more than a 25% FEV1 fall and symptoms.
- primary_references
- Intolerance to tartrazine in aspirin-induced asthma: results of a multicenter study. (1988). https://pubmed.ncbi.nlm.nih.gov/3387687/ DOI: 10.1159/000195391
- route
- Oral tartrazine; aspirin intolerance was a selection criterion, not co-administration
- tissue
- Oral challenge, spirometry and symptoms
Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 325–334
Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · 156 patients with confirmed aspirin-induced asthma in a multicenter study · source_derived_draft · unverified_draft
## tartrazine-aspirin-asthma Four of 156 aspirin-intolerant asthmatics had a double-blind-confirmed tartrazine response with more than a 25% FEV1 fall and symptoms. Model/species: 156 patients with confirmed aspirin-induced asthma in a multicenter study Tissue: Oral challenge, spirometry and symptoms Exposure: Increasing tartrazine doses up to 25 mg; positive open challenges repeated double blind Route: Oral tartrazine; aspirin intolerance was a selection criterion, not co-administration Duration: Acute challenge; exact observation window not specified in abstract Limits: Four confirmed reactions do not establish universal aspirin-tartrazine cross-reactivity or a shared IgE/COX mechanism. Results are specific to the recruited population. Primary reference: Intolerance to tartrazine in aspirin-induced asthma: results of a multicenter study. (1988). https://pubmed.ncbi.nlm.nih.gov/3387687/ DOI: 10.1159/000195391 Access: Primary PubMed abstract; unrecovered method details explicitly retained.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.