Component
Human radiculopathy outcomes after agmatine sulfate
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A randomized trial of 2.670 g/day oral agmatine sulfate for 14 days reported greater pain and quality-of-life improvements than placebo; 51 and 48 were randomized, but 31 and 30 were analyzed.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Lumbar disc-associated radiculopathy; double-blind placebo-controlled trial after dose escalation.
- limitations
- Short exposure and reduced analyzed sample limit inference; molecular mediation and general chronic-pain efficacy were not established.
- nutrient_topic
- Agmatine Sulfate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Agmatine Sulfate
- plain_language
- There is limited human outcome evidence, with substantial attrition to consider.
- primary_references
- Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20447305/ · DOI 10.1111/j.1526-4637.2010.00808.x
Agmatine Sulfate: transport, guanidino metabolism, ion channels and cross-nutrient mechanisms (2026-09-20) · lines 436–442
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Lumbar disc-associated radiculopathy; double-blind placebo-controlled trial after dose escalation. · source_derived_draft · unverified_draft
## agmatine-sulfate-oral-clinical There is limited human outcome evidence, with substantial attrition to consider. A randomized trial of 2.670 g/day oral agmatine sulfate for 14 days reported greater pain and quality-of-life improvements than placebo; 51 and 48 were randomized, but 31 and 30 were analyzed. Model: Lumbar disc-associated radiculopathy; double-blind placebo-controlled trial after dose escalation. Limitations: Short exposure and reduced analyzed sample limit inference; molecular mediation and general chronic-pain efficacy were not established. Evidence access: Primary abstract Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20447305/ · DOI 10.1111/j.1526-4637.2010.00808.x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.