Component
Coronary calcium-score progression in the aged garlic trial
Coronary calcium-score progression in the aged garlic trial. Interpret through the linked study species, preparation, exposure and measured endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The European AGE trial reported lower coronary calcium-score progression than placebo over one year.
Experimental context and source evidence
- evidence_access
- Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
- experimental_contrast
- {"intervention": "Specified aged garlic extract", "comparator": "Placebo", "endpoint": "The European AGE trial reported lower coronary calcium-score progression than placebo over one year.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- 104 randomized, 93 analyzed; 2.4 g/day AGE; baseline-adjusted analyses of imaging progression.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Retrospective trial registration, baseline imbalances and manufacturer support; surrogate imaging outcome, not plaque reversal or fewer cardiovascular events.
- plain_language
- The European AGE trial reported lower coronary calcium-score progression than placebo over one year.
- primary_references
- The effect of aged garlic extract on the atherosclerotic process - a randomized double-blind placebo-controlled trial. | 2020 | DOI 10.1186/s12906-020-02932-5 | PMID 32349742 | https://pubmed.ncbi.nlm.nih.gov/32349742/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC7191741/ | https://doi.org/10.1186/s12906-020-02932-5
- source_locator
- Reviewed reference lines 93-93; exact primary location described in quoted passage where extracted.
Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 93–93
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 104 randomized, 93 analyzed; 2.4 g/day AGE; baseline-adjusted analyses of imaging progression. · source_derived_draft · unverified_draft
**Coronary imaging.** A European trial randomized 104 participants to 2.4 g/day aged garlic extract or placebo for one year; ninety-three were analyzed. It reported lower coronary-calcium progression with the extract. It was retrospectively registered and received manufacturer funding and product support alongside other funding. Coronary calcium progression is an imaging outcome, not proof of plaque reversal, fewer infarctions, or allicin target engagement. It must remain distinct from low-attenuation plaque and total plaque-volume measurements. [Wlosinska 2020](https://pmc.ncbi.nlm.nih.gov/articles/PMC7191741/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.