Component
Human GRP78 / BiP / HSPA5
Human GRP78 / BiP / HSPA5. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Boric-acid treatment increased GRP78/BiP expression alongside the ATF6 response in DU-145 cells.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/boron-research/27587023.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "421c3ea56e2b1058bb780928a63bb648246560a0ba3a070d82dc3fdd37ff0725", "start_char": 0, "end_char": 1886, "text_sha256": "421c3ea56e2b1058bb780928a63bb648246560a0ba3a070d82dc3fdd37ff0725"}
- experimental_model
- Time-course immunoblotting and ER-stress gene expression
- exposure
- 10 µM boric acid; early time points from 30 minutes
- limitations
- Expression changes do not establish direct molecular targets or clinical effects. Total eIF2α abundance is distinct from Ser51 phosphorylation. The study did not activate every ER-stress branch.
- nutrient_topic
- Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
- organism
- Human DU-145 cells
- plain_language
- The cells increased an ER protein-folding helper.
- primary_references
- [boron-p27587023] Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake. (2017). https://pubmed.ncbi.nlm.nih.gov/27587023/ DOI: 10.1007/s12011-016-0824-y
- tissue_or_cell_type
- Prostate cancer cell culture
Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 443–454
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Time-course immunoblotting and ER-stress gene expression · source_derived_draft · unverified_draft
### boron-bip-expression Boric-acid treatment increased GRP78/BiP expression alongside the ATF6 response in DU-145 cells. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cells increased an ER protein-folding helper. organism: Human DU-145 cells tissue_or_cell_type: Prostate cancer cell culture experimental_model: Time-course immunoblotting and ER-stress gene expression limitations: Expression changes do not establish direct molecular targets or clinical effects. Total eIF2α abundance is distinct from Ser51 phosphorylation. The study did not activate every ER-stress branch. exposure: 10 µM boric acid; early time points from 30 minutes evidence_span: {"source_cache": "artifacts/boron-research/27587023.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "421c3ea56e2b1058bb780928a63bb648246560a0ba3a070d82dc3fdd37ff0725", "start_char": 0, "end_char": 1886, "text_sha256": "421c3ea56e2b1058bb780928a63bb648246560a0ba3a070d82dc3fdd37ff0725"} [boron-p27587023] Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake. (2017). https://pubmed.ncbi.nlm.nih.gov/27587023/ DOI: 10.1007/s12011-016-0824-y
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.