Component
Horse-liver NAD-dependent alcohol dehydrogenase
Horse-liver NAD-dependent alcohol dehydrogenase. Interpret through the linked study species, preparation, exposure and measured endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Allicin inhibited the tested purified horse-liver alcohol dehydrogenase.
Experimental context and source evidence
- evidence_access
- Primary indexed abstract reviewed; full methods, exact concentrations or species-specific attribution remain unextracted unless explicitly stated in the abstract or separately verified publisher text.
- experimental_contrast
- {"intervention": "Allicin incubation", "comparator": "Enzyme without allicin", "endpoint": "Allicin inhibited the tested purified horse-liver alcohol dehydrogenase.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Purified enzyme chemical-inhibition assay; species encoded in target.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Exact dose/time unextracted from the accessible abstract; thiol-mediated reversal is target-dependent, not universal irreversibility.
- plain_language
- Allicin inhibited the tested purified horse-liver alcohol dehydrogenase.
- primary_references
- The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. | 1998 | DOI 10.1016/s0304-4165(97)00104-9 | PMID 9528659 | https://pubmed.ncbi.nlm.nih.gov/9528659/ | https://doi.org/10.1016/s0304-4165(97)00104-9
- source_locator
- Reviewed reference lines 41-41; exact primary location described in quoted passage where extracted.
Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 41–41
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Purified enzyme chemical-inhibition assay; species encoded in target. · source_derived_draft · unverified_draft
**Enzyme inhibition and reversal differ by target.** The early purified-enzyme study observed inhibition of papain, bacterial NADP-dependent alcohol dehydrogenase, and horse-liver NAD-dependent alcohol dehydrogenase. Thiols could reactivate the enzymes, but not interchangeably: glutathione restored papain activity, whereas it did not restore the tested bacterial dehydrogenase under those conditions. Dithiothreitol or mercaptoethanol had different reversal profiles. Covalent inhibition is therefore not equivalent to unrecoverable injury, and a general glutathione rescue cannot be assumed for every enzyme. [Rabinkov 1998](https://pubmed.ncbi.nlm.nih.gov/9528659/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.