Component
Human HLA-B*35:01 allele carrier state
Human HLA-B*35:01 allele carrier state. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Seven of the ten patients carried HLA-B*35:01.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/curcumin-research/36252717.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f5f0d7db2b11e9ba6d176c45671428ac43c57cd8ce447873ea5fecd0d554244c", "start_char": 0, "end_char": 1722, "text_sha256": "f5f0d7db2b11e9ba6d176c45671428ac43c57cd8ce447873ea5fecd0d554244c"}
- experimental_model
- Expert-adjudicated DILIN case series with product testing and HLA typing
- exposure
- Ten cases associated with turmeric supplements; seven available products tested, three contained piperine
- limitations
- Case series cannot estimate incidence, assign every case to purified curcumin or establish that piperine caused the injury. HLA association is not a sufficient diagnostic test.
- nutrient_topic
- Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
- organism
- Homo sapiens
- plain_language
- A genetic association was observed, but it does not identify every susceptible person.
- primary_references
- [curcumin-p36252717] Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN]. (2023). https://pubmed.ncbi.nlm.nih.gov/36252717/ DOI: 10.1016/j.amjmed.2022.09.026
- tissue_or_cell_type
- Liver injury
Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1139–1150
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Expert-adjudicated DILIN case series with product testing and HLA typing · source_derived_draft · unverified_draft
### curcumin-hla-association Seven of the ten patients carried HLA-B*35:01. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A genetic association was observed, but it does not identify every susceptible person. organism: Homo sapiens tissue_or_cell_type: Liver injury experimental_model: Expert-adjudicated DILIN case series with product testing and HLA typing limitations: Case series cannot estimate incidence, assign every case to purified curcumin or establish that piperine caused the injury. HLA association is not a sufficient diagnostic test. exposure: Ten cases associated with turmeric supplements; seven available products tested, three contained piperine evidence_span: {"source_cache": "artifacts/curcumin-research/36252717.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f5f0d7db2b11e9ba6d176c45671428ac43c57cd8ce447873ea5fecd0d554244c", "start_char": 0, "end_char": 1722, "text_sha256": "f5f0d7db2b11e9ba6d176c45671428ac43c57cd8ce447873ea5fecd0d554244c"} [curcumin-p36252717] Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN]. (2023). https://pubmed.ncbi.nlm.nih.gov/36252717/ DOI: 10.1016/j.amjmed.2022.09.026
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.