Component
Apoptosis in human HL-60 cells
Apoptosis in human HL-60 cells. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Coumarin stimulated apoptosis in HL-60, but not the other cell lines tested in this study.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coumarin-research/7510710.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "723ca14ffacb7f7130fb0ae13e07174266395023f131be84d7b6a308c38dd21b", "start_char": 0, "end_char": 1368, "text_sha256": "723ca14ffacb7f7130fb0ae13e07174266395023f131be84d7b6a308c38dd21b"}
- experimental_model
- Dose/time exposure and washout in malignant cell lines
- exposure
- Coumarin and 7-hydroxycoumarin in cell culture
- limitations
- Cell-type-specific responses; no clinical anticancer efficacy inferred; concentrations not specified in indexed abstract.
- nutrient_topic
- Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
- organism
- Human cell lines
- plain_language
- The cell-death result depended on the cell line.
- primary_references
- [coumarin-p7510710] Growth-inhibitory effects of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin on human malignant cell lines in vitro. (1994). https://pubmed.ncbi.nlm.nih.gov/7510710/ DOI: 10.1007/bf01377114
- tissue_or_cell_type
- Study panel including HL-60, A549, LNCaP and other tumor lines
Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 436–447
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dose/time exposure and washout in malignant cell lines · source_derived_draft · unverified_draft
### coumarin-hl60-parent-apoptosis Coumarin stimulated apoptosis in HL-60, but not the other cell lines tested in this study. Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cell-death result depended on the cell line. organism: Human cell lines tissue_or_cell_type: Study panel including HL-60, A549, LNCaP and other tumor lines experimental_model: Dose/time exposure and washout in malignant cell lines limitations: Cell-type-specific responses; no clinical anticancer efficacy inferred; concentrations not specified in indexed abstract. exposure: Coumarin and 7-hydroxycoumarin in cell culture evidence_span: {"source_cache": "artifacts/coumarin-research/7510710.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "723ca14ffacb7f7130fb0ae13e07174266395023f131be84d7b6a308c38dd21b", "start_char": 0, "end_char": 1368, "text_sha256": "723ca14ffacb7f7130fb0ae13e07174266395023f131be84d7b6a308c38dd21b"} [coumarin-p7510710] Growth-inhibitory effects of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin on human malignant cell lines in vitro. (1994). https://pubmed.ncbi.nlm.nih.gov/7510710/ DOI: 10.1007/bf01377114
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.