Component
Monoacetylated histone H3/H4 assay peptides
Experimental histone peptides bearing a single acetylated lysine; not free dietary lysine.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Human SIRT2 deacetylated monoacetylated histone peptides in the NAD-consuming reaction producing nicotinamide and O-acetyl-ADP-ribose.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_span
- {"source_cache": "artifacts/niacin-consumption-sources/sirt22004.abstract.txt", "locator": "Indexed abstract", "start_char": 0, "end_char": 1423, "file_sha256": "a84f7d25c6e518d3317d4b0a41df8d8ac447cd3ef2966815c9818ca63116ef7f", "text_sha256": "a84f7d25c6e518d3317d4b0a41df8d8ac447cd3ef2966815c9818ca63116ef7f"}
- experimental_model
- Recombinant enzyme and monoacetylated histone H3/H4 peptide assays
- exposure
- Human SIRT2; yeast Sir2/Hst2 were also studied separately
- limitations
- Indexed abstract; rapid-kinetic details are not assigned to human SIRT2 individually. No dietary or longevity inference.
- nutrient_topic
- Niacin research collection; topical membership is not evidence of a direct dietary effect. · Niacin (vitamin B3)
- organism
- Human
- plain_language
- SIRT2 consumes NAD while removing acetyl groups from histone peptides.
- primary_references
- [b3-cons-sirt22004] Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. (2004). https://pubmed.ncbi.nlm.nih.gov/15274642/ DOI: 10.1021/bi049592e
- tissue_or_cell_type
- Cell-free assay
Niacin: NAD metabolism, deficiency and nutrient interactions (2026-09-17) · lines 551–563
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant enzyme and monoacetylated histone H3/H4 peptide assays · source_derived_draft · unverified_draft
### b3-cons-sirt2-reaction Human SIRT2 deacetylated monoacetylated histone peptides in the NAD-consuming reaction producing nicotinamide and O-acetyl-ADP-ribose. Condition category: normal nutrient_topic: Niacin research collection; topical membership is not evidence of a direct dietary effect. plain_language: SIRT2 consumes NAD while removing acetyl groups from histone peptides. organism: Human tissue_or_cell_type: Cell-free assay experimental_model: Recombinant enzyme and monoacetylated histone H3/H4 peptide assays limitations: Indexed abstract; rapid-kinetic details are not assigned to human SIRT2 individually. No dietary or longevity inference. exposure: Human SIRT2; yeast Sir2/Hst2 were also studied separately cross_nutrient: false evidence_span: {"source_cache": "artifacts/niacin-consumption-sources/sirt22004.abstract.txt", "locator": "Indexed abstract", "start_char": 0, "end_char": 1423, "file_sha256": "a84f7d25c6e518d3317d4b0a41df8d8ac447cd3ef2966815c9818ca63116ef7f", "text_sha256": "a84f7d25c6e518d3317d4b0a41df8d8ac447cd3ef2966815c9818ca63116ef7f"} [b3-cons-sirt22004] Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. (2004). https://pubmed.ncbi.nlm.nih.gov/15274642/ DOI: 10.1021/bi049592e
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.