Component
Human homeostatic iron regulator / HFE
Human homeostatic iron regulator / HFE. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
A major HFE missense alteration was homozygous in 83% of 178 hereditary-hemochromatosis patients in the discovery cohort.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/iron-research/8696333.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "812dfc62980bb4a17920e9eb490a2d1abc529b468c0531ffd59011713a60a15a", "start_char": 0, "end_char": 921, "text_sha256": "812dfc62980bb4a17920e9eb490a2d1abc529b468c0531ffd59011713a60a15a"}
- experimental_model
- Linkage disequilibrium and human genetic association
- exposure
- HFE discovery and missense variants
- limitations
- Historical selected population; 83% is not penetrance or a current general-population risk estimate.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- 178 hereditary-hemochromatosis patients in the reported cohort
- plain_language
- The body’s iron-control machinery can be defective even when dietary supply is ordinary.
- primary_references
- [iron-p8696333] A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. (1996). https://pubmed.ncbi.nlm.nih.gov/8696333/ DOI: 10.1038/ng0896-399
- tissue_or_cell_type
- Genetic iron-overload phenotype
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 1213–1224
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Linkage disequilibrium and human genetic association · source_derived_draft · unverified_draft
### iron-hfe-association A major HFE missense alteration was homozygous in 83% of 178 hereditary-hemochromatosis patients in the discovery cohort. Condition category: machinery_impairment nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The body’s iron-control machinery can be defective even when dietary supply is ordinary. organism: 178 hereditary-hemochromatosis patients in the reported cohort tissue_or_cell_type: Genetic iron-overload phenotype experimental_model: Linkage disequilibrium and human genetic association limitations: Historical selected population; 83% is not penetrance or a current general-population risk estimate. exposure: HFE discovery and missense variants evidence_span: {"source_cache": "artifacts/iron-research/8696333.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "812dfc62980bb4a17920e9eb490a2d1abc529b468c0531ffd59011713a60a15a", "start_char": 0, "end_char": 921, "text_sha256": "812dfc62980bb4a17920e9eb490a2d1abc529b468c0531ffd59011713a60a15a"} [iron-p8696333] A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. (1996). https://pubmed.ncbi.nlm.nih.gov/8696333/ DOI: 10.1038/ng0896-399
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.