Component
Hepatic fibrosis score
Hepatic fibrosis score. Read linked claims for the population, experiment and limits.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Vitamin E did not significantly improve fibrosis scores in PIVENS (P=0.24 versus placebo).
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- PIVENS randomized double-blind trial; 247 adults with biopsy-confirmed NASH without diabetes
- exposure
- RRR-alpha-tocopherol 800 IU/day for 96 weeks; E group n=84, placebo n=83.
- limitations
- Histological endpoints in a defined nondiabetic NASH population, not proof of general liver benefit, fibrosis reversal, cirrhosis prevention or long-term survival benefit.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- The liver-biopsy benefit did not establish fibrosis reversal.
- primary_references
- [e-clin-pivens2010] Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. (2010). https://pubmed.ncbi.nlm.nih.gov/20427778/ DOI: 10.1056/nejmoa0907929
- tissue_or_cell_type
- Liver biopsy
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 1414–1425
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · PIVENS randomized double-blind trial; 247 adults with biopsy-confirmed NASH without diabetes · source_derived_draft · unverified_draft
### e-clin-pivens-fibrosis Vitamin E did not significantly improve fibrosis scores in PIVENS (P=0.24 versus placebo). Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: The liver-biopsy benefit did not establish fibrosis reversal. organism: Homo sapiens tissue_or_cell_type: Liver biopsy experimental_model: PIVENS randomized double-blind trial; 247 adults with biopsy-confirmed NASH without diabetes limitations: Histological endpoints in a defined nondiabetic NASH population, not proof of general liver benefit, fibrosis reversal, cirrhosis prevention or long-term survival benefit. exposure: RRR-alpha-tocopherol 800 IU/day for 96 weeks; E group n=84, placebo n=83. cross_nutrient: false [e-clin-pivens2010] Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. (2010). https://pubmed.ncbi.nlm.nih.gov/20427778/ DOI: 10.1056/nejmoa0907929
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.