Component
Hemorrhagic stroke incidence
Hemorrhagic stroke incidence. Read linked claims for the population, experiment and limits.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
PHS II found increased hemorrhagic-stroke incidence with vitamin E assignment (HR 1.74, 95% CI 1.04–2.91).
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Physicians Health Study II randomized factorial trial; 14641 male US physicians aged at least 50
- exposure
- Synthetic alpha-tocopherol 400 IU on alternate days, with factorial vitamin C 500 mg/day; mean follow-up 8 years.
- limitations
- Mostly primary prevention in male physicians; historical regimen is not nutritional repletion. Primary Methods specify synthetic alpha-tocopherol; no unverified ester identity is attached. The clinical endpoint does not prove that altered vitamin K metabolism caused these events.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- A bleeding-related stroke outcome increased in this trial.
- primary_references
- [e-clin-phs2008] Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. (2008). https://pubmed.ncbi.nlm.nih.gov/18997197/ DOI: 10.1001/jama.2008.600
- tissue_or_cell_type
- Cardiovascular clinical events
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 1362–1373
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Physicians Health Study II randomized factorial trial; 14641 male US physicians aged at least 50 · source_derived_draft · unverified_draft
### e-clin-phs-hemorrhagic-stroke PHS II found increased hemorrhagic-stroke incidence with vitamin E assignment (HR 1.74, 95% CI 1.04–2.91). Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: A bleeding-related stroke outcome increased in this trial. organism: Homo sapiens tissue_or_cell_type: Cardiovascular clinical events experimental_model: Physicians Health Study II randomized factorial trial; 14641 male US physicians aged at least 50 limitations: Mostly primary prevention in male physicians; historical regimen is not nutritional repletion. Primary Methods specify synthetic alpha-tocopherol; no unverified ester identity is attached. The clinical endpoint does not prove that altered vitamin K metabolism caused these events. exposure: Synthetic alpha-tocopherol 400 IU on alternate days, with factorial vitamin C 500 mg/day; mean follow-up 8 years. cross_nutrient: false [e-clin-phs2008] Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. (2008). https://pubmed.ncbi.nlm.nih.gov/18997197/ DOI: 10.1001/jama.2008.600
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.