Component
Mitochondrial cytochrome c release in HeLa cells
Mitochondrial cytochrome c release in HeLa cells. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Coumarin promoted cytochrome c release from HeLa mitochondria.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coumarin-research/18210747.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e78df713d6bc2e34f13e80a0ef04c217a176b5d6082cbb28fa5a62464fcce842", "start_char": 0, "end_char": 1237, "text_sha256": "e78df713d6bc2e34f13e80a0ef04c217a176b5d6082cbb28fa5a62464fcce842"}
- experimental_model
- Cell viability, cell cycle, protein and mitochondrial assays
- exposure
- Coumarin; reported viability IC50 54.2 micromolar
- limitations
- Cultured cancer-cell response does not establish treatment efficacy; indexed abstract does not specify all exposure durations.
- nutrient_topic
- Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
- organism
- Human cell line
- plain_language
- A mitochondrial signal entered the cell-death pathway.
- primary_references
- [coumarin-p18210747] Coumarin induces cell cycle arrest and apoptosis in human cervical cancer HeLa cells through a mitochondria- and caspase-3 dependent mechanism and NF-kappaB down-regulation. (2007). https://pubmed.ncbi.nlm.nih.gov/18210747/
- tissue_or_cell_type
- HeLa cervical cancer cells
Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 384–395
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cell viability, cell cycle, protein and mitochondrial assays · source_derived_draft · unverified_draft
### coumarin-hela-cytc Coumarin promoted cytochrome c release from HeLa mitochondria. Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A mitochondrial signal entered the cell-death pathway. organism: Human cell line tissue_or_cell_type: HeLa cervical cancer cells experimental_model: Cell viability, cell cycle, protein and mitochondrial assays limitations: Cultured cancer-cell response does not establish treatment efficacy; indexed abstract does not specify all exposure durations. exposure: Coumarin; reported viability IC50 54.2 micromolar evidence_span: {"source_cache": "artifacts/coumarin-research/18210747.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e78df713d6bc2e34f13e80a0ef04c217a176b5d6082cbb28fa5a62464fcce842", "start_char": 0, "end_char": 1237, "text_sha256": "e78df713d6bc2e34f13e80a0ef04c217a176b5d6082cbb28fa5a62464fcce842"} [coumarin-p18210747] Coumarin induces cell cycle arrest and apoptosis in human cervical cancer HeLa cells through a mitochondria- and caspase-3 dependent mechanism and NF-kappaB down-regulation. (2007). https://pubmed.ncbi.nlm.nih.gov/18210747/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.