Component
HC-030031 TRPA1 antagonist
HC-030031 TRPA1 antagonist. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
HC-030031 at 100 micromolar abolished the cinnamaldehyde-induced calcium influx in isolated rat islets.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/ceylon-research/37631083.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "81c61f935e3b9e0e16acb5e76bd56be59ca99bea4e3da001710e6d994abb92e7", "start_char": 14083, "end_char": 20148, "text_sha256": "c4c3a9bf3331afd13074d335e0130614002673a177990f17495f0c9d893af7c4"}
- experimental_model
- Rat glucose challenges and isolated intestinal/islet experiments
- exposure
- Cinnamaldehyde 5–20 mg/kg intraperitoneal in vivo; islet calcium experiment 100 micromolar for 10 minutes
- limitations
- Injection is not spice ingestion. Antagonists and calcium chelation probe machinery, not dietary mineral inadequacy.
- nutrient_topic
- Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
- organism
- Rat
- plain_language
- Blocking TRPA1 removed the measured calcium response.
- primary_references
- [ceylon-p37631083] Electrophilic Agonists Modulate the Transient Receptor Potential Ankyrin-1 Channels Mediated by Insulin and Glucagon-like Peptide-1 Secretion for Glucose Homeostasis. (2023). https://pubmed.ncbi.nlm.nih.gov/37631083/ DOI: 10.3390/ph16081167
- tissue_or_cell_type
- Intestine and pancreatic islets
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 428–439
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat glucose challenges and isolated intestinal/islet experiments · source_derived_draft · unverified_draft
### ceylon-trpa1-block HC-030031 at 100 micromolar abolished the cinnamaldehyde-induced calcium influx in isolated rat islets. Condition category: machinery_impairment nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blocking TRPA1 removed the measured calcium response. organism: Rat tissue_or_cell_type: Intestine and pancreatic islets experimental_model: Rat glucose challenges and isolated intestinal/islet experiments limitations: Injection is not spice ingestion. Antagonists and calcium chelation probe machinery, not dietary mineral inadequacy. exposure: Cinnamaldehyde 5–20 mg/kg intraperitoneal in vivo; islet calcium experiment 100 micromolar for 10 minutes evidence_span: {"source_cache": "artifacts/ceylon-research/37631083.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "81c61f935e3b9e0e16acb5e76bd56be59ca99bea4e3da001710e6d994abb92e7", "start_char": 14083, "end_char": 20148, "text_sha256": "c4c3a9bf3331afd13074d335e0130614002673a177990f17495f0c9d893af7c4"} [ceylon-p37631083] Electrophilic Agonists Modulate the Transient Receptor Potential Ankyrin-1 Channels Mediated by Insulin and Glucagon-like Peptide-1 Secretion for Glucose Homeostasis. (2023). https://pubmed.ncbi.nlm.nih.gov/37631083/ DOI: 10.3390/ph16081167
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.