Component
Gut bacterial dysbiosis
Gut bacterial dysbiosis. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Intestinal permeability and gut bacterial dysbiosis were associated with behavioural markers of alcohol-dependence severity.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/alcohol-research/25288760.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b62793e216036689dd924357291c4512c5e9bcf7e7b41429e6bb72b2022f6a6c", "start_char": 0, "end_char": 1345, "text_sha256": "b62793e216036689dd924357291c4512c5e9bcf7e7b41429e6bb72b2022f6a6c"}
- experimental_model
- Alcohol-dependent patients with permeability, microbiome and behavioural measures
- exposure
- Alcohol dependence with detoxification
- limitations
- Links the gut measurements to craving. It is an association in a dependent population, and the direction of causation is not established.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Human
- plain_language
- How leaky the gut is tracks with how severe the dependence is.
- primary_references
- [alcohol-p25288760] Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. (2014). https://pubmed.ncbi.nlm.nih.gov/25288760/ DOI: 10.1073/pnas.1415174111
- tissue_or_cell_type
- Intestine and behaviour
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 488–499
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Alcohol-dependent patients with permeability, microbiome and behavioural measures · source_derived_draft · unverified_draft
### alcohol-permeability-craving Intestinal permeability and gut bacterial dysbiosis were associated with behavioural markers of alcohol-dependence severity. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: How leaky the gut is tracks with how severe the dependence is. organism: Human tissue_or_cell_type: Intestine and behaviour experimental_model: Alcohol-dependent patients with permeability, microbiome and behavioural measures limitations: Links the gut measurements to craving. It is an association in a dependent population, and the direction of causation is not established. exposure: Alcohol dependence with detoxification evidence_span: {"source_cache": "artifacts/alcohol-research/25288760.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b62793e216036689dd924357291c4512c5e9bcf7e7b41429e6bb72b2022f6a6c", "start_char": 0, "end_char": 1345, "text_sha256": "b62793e216036689dd924357291c4512c5e9bcf7e7b41429e6bb72b2022f6a6c"} [alcohol-p25288760] Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. (2014). https://pubmed.ncbi.nlm.nih.gov/25288760/ DOI: 10.1073/pnas.1415174111
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.