Component

Alcohol craving and dependence severity

Alcohol craving and dependence severity. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Intestinal permeability and gut bacterial dysbiosis were associated with behavioural markers of alcohol-dependence severity.

    Intestinal permeability to macromolecules → Alcohol craving and dependence severity source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/alcohol-research/25288760.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b62793e216036689dd924357291c4512c5e9bcf7e7b41429e6bb72b2022f6a6c", "start_char": 0, "end_char": 1345, "text_sha256": "b62793e216036689dd924357291c4512c5e9bcf7e7b41429e6bb72b2022f6a6c"}
    experimental_model
    Alcohol-dependent patients with permeability, microbiome and behavioural measures
    exposure
    Alcohol dependence with detoxification
    limitations
    Links the gut measurements to craving. It is an association in a dependent population, and the direction of causation is not established.
    nutrient_topic
    Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
    organism
    Human
    plain_language
    How leaky the gut is tracks with how severe the dependence is.
    primary_references
    [alcohol-p25288760] Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. (2014). https://pubmed.ncbi.nlm.nih.gov/25288760/ DOI: 10.1073/pnas.1415174111
    tissue_or_cell_type
    Intestine and behaviour

    Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 488–499

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Alcohol-dependent patients with permeability, microbiome and behavioural measures · source_derived_draft · unverified_draft

    ### alcohol-permeability-craving Intestinal permeability and gut bacterial dysbiosis were associated with behavioural markers of alcohol-dependence severity. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: How leaky the gut is tracks with how severe the dependence is. organism: Human tissue_or_cell_type: Intestine and behaviour experimental_model: Alcohol-dependent patients with permeability, microbiome and behavioural measures limitations: Links the gut measurements to craving. It is an association in a dependent population, and the direction of causation is not established. exposure: Alcohol dependence with detoxification evidence_span: {"source_cache": "artifacts/alcohol-research/25288760.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b62793e216036689dd924357291c4512c5e9bcf7e7b41429e6bb72b2022f6a6c", "start_char": 0, "end_char": 1345, "text_sha256": "b62793e216036689dd924357291c4512c5e9bcf7e7b41429e6bb72b2022f6a6c"} [alcohol-p25288760] Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. (2014). https://pubmed.ncbi.nlm.nih.gov/25288760/ DOI: 10.1073/pnas.1415174111
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Long-acting injectable naltrexone reduced heavy drinking in a randomised controlled trial in alcohol dependence, with acceptable tolerability.

    Naltrexone → Proportion of heavy drinking days source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/alcohol-research/15811981.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bb7a465c529de6ca90435bf684f771315d916f418979902fd0af0a7d712eaa3f", "start_char": 0, "end_char": 2211, "text_sha256": "bb7a465c529de6ca90435bf684f771315d916f418979902fd0af0a7d712eaa3f"}
    experimental_model
    Randomised controlled trial of long-acting injectable naltrexone
    exposure
    Monthly injectable naltrexone versus placebo
    limitations
    A large randomised trial of a depot formulation, which removes the adherence problem of daily dosing.
    nutrient_topic
    Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
    organism
    Human
    plain_language
    A monthly injection of the same blocker worked too.
    primary_references
    [alcohol-p15811981] Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. (2005). https://pubmed.ncbi.nlm.nih.gov/15811981/ DOI: 10.1001/jama.293.13.1617
    tissue_or_cell_type
    Whole body

    Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 618–629

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomised controlled trial of long-acting injectable naltrexone · source_derived_draft · unverified_draft

    ### alcohol-naltrexone-depot Long-acting injectable naltrexone reduced heavy drinking in a randomised controlled trial in alcohol dependence, with acceptable tolerability. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: A monthly injection of the same blocker worked too. organism: Human tissue_or_cell_type: Whole body experimental_model: Randomised controlled trial of long-acting injectable naltrexone limitations: A large randomised trial of a depot formulation, which removes the adherence problem of daily dosing. exposure: Monthly injectable naltrexone versus placebo evidence_span: {"source_cache": "artifacts/alcohol-research/15811981.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bb7a465c529de6ca90435bf684f771315d916f418979902fd0af0a7d712eaa3f", "start_char": 0, "end_char": 2211, "text_sha256": "bb7a465c529de6ca90435bf684f771315d916f418979902fd0af0a7d712eaa3f"} [alcohol-p15811981] Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. (2005). https://pubmed.ncbi.nlm.nih.gov/15811981/ DOI: 10.1001/jama.293.13.1617
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards