Component
Guinea pig sodium-dependent vitamin C transporter 2 / Slc23a2
Guinea pig sodium-dependent vitamin C transporter 2 / Slc23a2
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Dietary vitamin C restriction did not significantly alter SVCT2 mRNA or protein in guinea pig hippocampus, cerebellum or frontal cortex at day 70.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Thirty female guinea pig offspring, control/deficient/repleted diets, postnatal day 70
- exposure
- Prenatal/postnatal 100/100 mg vitamin C/kg diet versus 900/750 mg/kg controls; female offspring at day 70
- limitations
- No detected expression difference is not proof of unchanged transport flux, earlier expression, or every cell subtype.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Cavia porcellus
- plain_language
- The measured brain regions did not compensate by detectably increasing SVCT2 abundance.
- primary_references
- [brain2014] Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression. (2014). https://pubmed.ncbi.nlm.nih.gov/24787032/ DOI: 10.3390/nu6051809
- tissue_or_cell_type
- Hippocampus, cerebellum and frontal cortex
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 481–492
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Thirty female guinea pig offspring, control/deficient/repleted diets, postnatal day 70 · source_derived_draft · unverified_draft
### vc-transport-diet-brain-svct2 Dietary vitamin C restriction did not significantly alter SVCT2 mRNA or protein in guinea pig hippocampus, cerebellum or frontal cortex at day 70. Condition category: nutrient_deficiency nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: The measured brain regions did not compensate by detectably increasing SVCT2 abundance. organism: Cavia porcellus tissue_or_cell_type: Hippocampus, cerebellum and frontal cortex experimental_model: Thirty female guinea pig offspring, control/deficient/repleted diets, postnatal day 70 limitations: No detected expression difference is not proof of unchanged transport flux, earlier expression, or every cell subtype. exposure: Prenatal/postnatal 100/100 mg vitamin C/kg diet versus 900/750 mg/kg controls; female offspring at day 70 cross_nutrient: false [brain2014] Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression. (2014). https://pubmed.ncbi.nlm.nih.gov/24787032/ DOI: 10.3390/nu6051809
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.