Component
NMDA receptor subunit GluN1 / GRIN1
NMDA receptor subunit GluN1 / GRIN1. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Ethanol inhibited NMDA-activated ion current in hippocampal neurons at concentrations reached during intoxication.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/alcohol-research/2467382.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c968c9a63cb2826e3986e1fd13f83fdf231adc1d46e0bc9aa73882cce6f0dca1", "start_char": 0, "end_char": 844, "text_sha256": "c968c9a63cb2826e3986e1fd13f83fdf231adc1d46e0bc9aa73882cce6f0dca1"}
- experimental_model
- Whole-cell recording from dissociated hippocampal neurons
- exposure
- Ethanol at intoxicating concentrations applied to NMDA-activated current
- limitations
- The founding electrophysiology result for this target. Concentrations are in the intoxicating range, which is what makes it relevant to drinking.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Rat
- plain_language
- Alcohol shuts down the brain’s main excitatory receptor at the doses people actually drink.
- primary_references
- [alcohol-p2467382] Ethanol inhibits NMDA-activated ion current in hippocampal neurons. (1989). https://pubmed.ncbi.nlm.nih.gov/2467382/ DOI: 10.1126/science.2467382
- tissue_or_cell_type
- Hippocampal neurons
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 280–291
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Whole-cell recording from dissociated hippocampal neurons · source_derived_draft · unverified_draft
### alcohol-nmda-inhibition Ethanol inhibited NMDA-activated ion current in hippocampal neurons at concentrations reached during intoxication. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: Alcohol shuts down the brain’s main excitatory receptor at the doses people actually drink. organism: Rat tissue_or_cell_type: Hippocampal neurons experimental_model: Whole-cell recording from dissociated hippocampal neurons limitations: The founding electrophysiology result for this target. Concentrations are in the intoxicating range, which is what makes it relevant to drinking. exposure: Ethanol at intoxicating concentrations applied to NMDA-activated current evidence_span: {"source_cache": "artifacts/alcohol-research/2467382.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c968c9a63cb2826e3986e1fd13f83fdf231adc1d46e0bc9aa73882cce6f0dca1", "start_char": 0, "end_char": 844, "text_sha256": "c968c9a63cb2826e3986e1fd13f83fdf231adc1d46e0bc9aa73882cce6f0dca1"} [alcohol-p2467382] Ethanol inhibits NMDA-activated ion current in hippocampal neurons. (1989). https://pubmed.ncbi.nlm.nih.gov/2467382/ DOI: 10.1126/science.2467382
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.