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(1989). https://pubmed.ncbi.nlm.nih.gov/2467382/ DOI: 10.1126/science.2467382","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Hippocampal neurons","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"efc24497-41bd-5450-b5d3-938c485b832d","evidence_kind":"source_excerpt","locator":"Lines 280-291","start_line":280,"end_line":291,"excerpt":"### alcohol-nmda-inhibition\nEthanol inhibited NMDA-activated ion current in hippocampal neurons at concentrations reached during intoxication.\nCondition category: normal\nnutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.\nplain_language: Alcohol shuts down the brain’s main excitatory receptor at the doses people actually drink.\norganism: Rat\ntissue_or_cell_type: Hippocampal neurons\nexperimental_model: Whole-cell recording from dissociated hippocampal neurons\nlimitations: The founding electrophysiology result for this target. Concentrations are in the intoxicating range, which is what makes it relevant to drinking.\nexposure: Ethanol at intoxicating concentrations applied to NMDA-activated current\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/2467382.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c968c9a63cb2826e3986e1fd13f83fdf231adc1d46e0bc9aa73882cce6f0dca1\", \"start_char\": 0, \"end_char\": 844, \"text_sha256\": \"c968c9a63cb2826e3986e1fd13f83fdf231adc1d46e0bc9aa73882cce6f0dca1\"}\n[alcohol-p2467382] Ethanol inhibits NMDA-activated ion current in hippocampal neurons. (1989). https://pubmed.ncbi.nlm.nih.gov/2467382/ DOI: 10.1126/science.2467382","model_system":"Whole-cell recording from dissociated hippocampal neurons","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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