Calcium import into the Golgi lumen: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

Human SPCA1a also transports calcium; calcium and manganese occupy the same transmembrane pocket in the respective structures.
Human SPCA1 isoform a → Calcium import into the Golgi lumen source_derived_draftungraded
Experimental context and source evidence
cross_nutrient
calcium ion (transported_ion); Manganese(II) ion (alternative_ion); Adenosine triphosphate (energy_substrate); Golgi apparatus (destination)
evidence_span
{"source_cache": "artifacts/manganese-glycosylation-sources/spca2023.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "06a3eac4cc4e989b9195bdb14847c868ddaa68935a12f2d5c5f50a1a47259fb8", "start_char": 0, "end_char": 1276, "text_sha256": "06a3eac4cc4e989b9195bdb14847c868ddaa68935a12f2d5c5f50a1a47259fb8", "text_characters": 1276}
experimental_model
Cryo-EM of purified human SPCA1a with ATP and divalent ions
exposure
ATP/Ca2+, ATP/Mn2+ and phosphorylated metal-free structural states.
limitations
Structural states explain the transport cycle but do not supply a dietary requirement or prove that calcium supplementation impairs manganese delivery.
nutrient_topic
Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
organism
Homo sapiens
plain_language
The same pump handles calcium and manganese through a shared site.
primary_references
[mn-gly-spca2023] Cryo-EM structures of human SPCA1a reveal the mechanism of Ca2+/Mn2+ transport into the Golgi apparatus. (2023). https://pubmed.ncbi.nlm.nih.gov/36867705/ DOI: 10.1126/sciadv.add9742
tissue_or_cell_type
Golgi membrane transport protein
transport_effect
raises The object already names import into the Golgi lumen.
transport_pool
the Golgi lumen The object already names import into the Golgi lumen.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 712–724
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cryo-EM of purified human SPCA1a with ATP and divalent ions · source_derived_draft · unverified_draft
### mn-gly-spca-calcium Human SPCA1a also transports calcium; calcium and manganese occupy the same transmembrane pocket in the respective structures. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same pump handles calcium and manganese through a shared site. organism: Homo sapiens tissue_or_cell_type: Golgi membrane transport protein experimental_model: Cryo-EM of purified human SPCA1a with ATP and divalent ions limitations: Structural states explain the transport cycle but do not supply a dietary requirement or prove that calcium supplementation impairs manganese delivery. exposure: ATP/Ca2+, ATP/Mn2+ and phosphorylated metal-free structural states. cross_nutrient: calcium ion (transported_ion); Manganese(II) ion (alternative_ion); Adenosine triphosphate (energy_substrate); Golgi apparatus (destination) evidence_span: {"source_cache": "artifacts/manganese-glycosylation-sources/spca2023.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "06a3eac4cc4e989b9195bdb14847c868ddaa68935a12f2d5c5f50a1a47259fb8", "start_char": 0, "end_char": 1276, "text_sha256": "06a3eac4cc4e989b9195bdb14847c868ddaa68935a12f2d5c5f50a1a47259fb8", "text_characters": 1276} [mn-gly-spca2023] Cryo-EM structures of human SPCA1a reveal the mechanism of Ca2+/Mn2+ transport into the Golgi apparatus. (2023). https://pubmed.ncbi.nlm.nih.gov/36867705/ DOI: 10.1126/sciadv.add9742
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Calcium import into the Golgi lumen