Component

Glycine plus N-acetylcysteine in the 114-participant two-week trial

Glycine plus N-acetylcysteine in the 114-participant two-week trial. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. GlyNAC did not significantly improve the GSH:GSSG ratio; high-dose versus placebo p=0.739.

    Glycine plus N-acetylcysteine in the 114-participant two-week trial → Blood reduced-to-oxidized glutathione ratio in the 114-participant GlyNAC trial source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/glutathione-research/35821844.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3", "start_char": 0, "end_char": 2083, "text_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3"}
    experimental_model
    Randomized controlled dose-ranging trial
    exposure
    2.4, 4.8 or 7.2 g/day GlyNAC, 1:1 ratio, for two weeks
    limitations
    Primary outcomes were null; the favorable low-GSH/high-MDA subgroup was post hoc and hypothesis-generating.
    nutrient_topic
    Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
    organism
    Human
    plain_language
    Adding precursors did not reliably improve redox status in the overall trial.
    primary_references
    [glutathione-p35821844] A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage. (2022). https://pubmed.ncbi.nlm.nih.gov/35821844/ DOI: 10.3389/fragi.2022.852569
    tissue_or_cell_type
    114 healthy older volunteers; 20 young reference participants

    Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 1256–1267

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized controlled dose-ranging trial · source_derived_draft · unverified_draft

    ### glutathione-glynac-large-ratio-null GlyNAC did not significantly improve the GSH:GSSG ratio; high-dose versus placebo p=0.739. Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: Adding precursors did not reliably improve redox status in the overall trial. organism: Human tissue_or_cell_type: 114 healthy older volunteers; 20 young reference participants experimental_model: Randomized controlled dose-ranging trial limitations: Primary outcomes were null; the favorable low-GSH/high-MDA subgroup was post hoc and hypothesis-generating. exposure: 2.4, 4.8 or 7.2 g/day GlyNAC, 1:1 ratio, for two weeks evidence_span: {"source_cache": "artifacts/glutathione-research/35821844.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3", "start_char": 0, "end_char": 2083, "text_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3"} [glutathione-p35821844] A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage. (2022). https://pubmed.ncbi.nlm.nih.gov/35821844/ DOI: 10.3389/fragi.2022.852569
    Complete structured claim and evidence

  2. The primary total-GSH endpoint was not significantly increased; high-dose versus placebo p=0.278.

    Glycine plus N-acetylcysteine in the 114-participant two-week trial → Total blood glutathione in the 114-participant GlyNAC trial source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/glutathione-research/35821844.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3", "start_char": 0, "end_char": 2083, "text_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3"}
    experimental_model
    Randomized controlled dose-ranging trial
    exposure
    2.4, 4.8 or 7.2 g/day GlyNAC, 1:1 ratio, for two weeks
    limitations
    Primary outcomes were null; the favorable low-GSH/high-MDA subgroup was post hoc and hypothesis-generating.
    nutrient_topic
    Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
    organism
    Human
    plain_language
    The main trial result must remain visible alongside favorable subsets.
    primary_references
    [glutathione-p35821844] A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage. (2022). https://pubmed.ncbi.nlm.nih.gov/35821844/ DOI: 10.3389/fragi.2022.852569
    tissue_or_cell_type
    114 healthy older volunteers; 20 young reference participants

    Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 1269–1280

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized controlled dose-ranging trial · source_derived_draft · unverified_draft

    ### glutathione-glynac-large-total-null The primary total-GSH endpoint was not significantly increased; high-dose versus placebo p=0.278. Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: The main trial result must remain visible alongside favorable subsets. organism: Human tissue_or_cell_type: 114 healthy older volunteers; 20 young reference participants experimental_model: Randomized controlled dose-ranging trial limitations: Primary outcomes were null; the favorable low-GSH/high-MDA subgroup was post hoc and hypothesis-generating. exposure: 2.4, 4.8 or 7.2 g/day GlyNAC, 1:1 ratio, for two weeks evidence_span: {"source_cache": "artifacts/glutathione-research/35821844.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3", "start_char": 0, "end_char": 2083, "text_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3"} [glutathione-p35821844] A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage. (2022). https://pubmed.ncbi.nlm.nih.gov/35821844/ DOI: 10.3389/fragi.2022.852569
    Complete structured claim and evidence

  3. A post-hoc high-MDA/low-baseline-GSH subgroup had higher total GSH with pooled medium/high doses (p=0.016).

    Glycine plus N-acetylcysteine in the 114-participant two-week trial → Total glutathione in the high-stress/low-baseline-GSH post-hoc trial subset source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/glutathione-research/35821844.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3", "start_char": 0, "end_char": 2083, "text_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3"}
    experimental_model
    Randomized controlled dose-ranging trial
    exposure
    2.4, 4.8 or 7.2 g/day GlyNAC, 1:1 ratio, for two weeks
    limitations
    Primary outcomes were null; the favorable low-GSH/high-MDA subgroup was post hoc and hypothesis-generating.
    nutrient_topic
    Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
    organism
    Human
    plain_language
    A subgroup signal needs confirmation in a prespecified trial.
    primary_references
    [glutathione-p35821844] A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage. (2022). https://pubmed.ncbi.nlm.nih.gov/35821844/ DOI: 10.3389/fragi.2022.852569
    tissue_or_cell_type
    114 healthy older volunteers; 20 young reference participants

    Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 1282–1293

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized controlled dose-ranging trial · source_derived_draft · unverified_draft

    ### glutathione-glynac-posthoc A post-hoc high-MDA/low-baseline-GSH subgroup had higher total GSH with pooled medium/high doses (p=0.016). Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: A subgroup signal needs confirmation in a prespecified trial. organism: Human tissue_or_cell_type: 114 healthy older volunteers; 20 young reference participants experimental_model: Randomized controlled dose-ranging trial limitations: Primary outcomes were null; the favorable low-GSH/high-MDA subgroup was post hoc and hypothesis-generating. exposure: 2.4, 4.8 or 7.2 g/day GlyNAC, 1:1 ratio, for two weeks evidence_span: {"source_cache": "artifacts/glutathione-research/35821844.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3", "start_char": 0, "end_char": 2083, "text_sha256": "843ee2e21e49023605a628216fb9c3c4c69ca1d8f3bb19d10da85d038d6612f3"} [glutathione-p35821844] A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage. (2022). https://pubmed.ncbi.nlm.nih.gov/35821844/ DOI: 10.3389/fragi.2022.852569
    Complete structured claim and evidence

In the sources

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    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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