Component
Human muscle GLUT4 translocation to the sarcolemma
Human muscle GLUT4 translocation to the sarcolemma. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Creatine plus exercise increased muscle GLUT4 translocation to the sarcolemma relative to placebo plus exercise.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/creatine-research/20881878.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b3ba6f24e6aedc2c8220a6b50f5d315fc4f885740bc1934cf438cbe0865ace52", "start_char": 0, "end_char": 1736, "text_sha256": "b3ba6f24e6aedc2c8220a6b50f5d315fc4f885740bc1934cf438cbe0865ace52"}
- experimental_model
- Twelve-week randomized double-blind trial with exercise in both arms
- exposure
- Creatine 5 g/day plus exercise versus placebo plus exercise
- limitations
- Small adjunct-to-exercise trial; no replacement for diabetes treatment or isolated creatine effect without exercise is established.
- nutrient_topic
- Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
- organism
- 25 adults with type 2 diabetes
- plain_language
- More of the glucose transporter was located at the muscle-cell surface in this trial.
- primary_references
- [creatine-p20881878] Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial. (2011). https://pubmed.ncbi.nlm.nih.gov/20881878/ DOI: 10.1249/mss.0b013e3181fcee7d
- tissue_or_cell_type
- Blood glucose regulation and muscle GLUT4 localization
Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 997–1008
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twelve-week randomized double-blind trial with exercise in both arms · source_derived_draft · unverified_draft
### creatine-diabetes-glut4 Creatine plus exercise increased muscle GLUT4 translocation to the sarcolemma relative to placebo plus exercise. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: More of the glucose transporter was located at the muscle-cell surface in this trial. organism: 25 adults with type 2 diabetes tissue_or_cell_type: Blood glucose regulation and muscle GLUT4 localization experimental_model: Twelve-week randomized double-blind trial with exercise in both arms limitations: Small adjunct-to-exercise trial; no replacement for diabetes treatment or isolated creatine effect without exercise is established. exposure: Creatine 5 g/day plus exercise versus placebo plus exercise evidence_span: {"source_cache": "artifacts/creatine-research/20881878.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b3ba6f24e6aedc2c8220a6b50f5d315fc4f885740bc1934cf438cbe0865ace52", "start_char": 0, "end_char": 1736, "text_sha256": "b3ba6f24e6aedc2c8220a6b50f5d315fc4f885740bc1934cf438cbe0865ace52"} [creatine-p20881878] Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial. (2011). https://pubmed.ncbi.nlm.nih.gov/20881878/ DOI: 10.1249/mss.0b013e3181fcee7d
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.