Component
Human GLRX5 [2Fe-2S]-glutathione complex
Human GLRX5 [2Fe-2S]-glutathione complex. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Each GLRX5-bound [2Fe-2S] cluster was ligated by two protein Cys67 thiols and two GSH cysteine thiols.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/glutathione-research/21029046.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bc7e33127eee3685d1f90bff5a83334d68ac0ee3f73eeb67e4a9e189c5ba20b2", "start_char": 0, "end_char": 1468, "text_sha256": "bc7e33127eee3685d1f90bff5a83334d68ac0ee3f73eeb67e4a9e189c5ba20b2"}
- experimental_model
- Crystallography, solution oligomers and biochemical assays
- exposure
- Iron-sulfur/GSH complex and disulfide assays
- limitations
- The structural cluster complex is not a dietary-iron requirement or proof of supplement synergy.
- nutrient_topic
- Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
- organism
- Human GLRX5
- plain_language
- Glutathione is part of the cluster-binding structure, not only an antioxidant.
- primary_references
- [glutathione-p21029046] The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity. (2011). https://pubmed.ncbi.nlm.nih.gov/21029046/ DOI: 10.1042/bj20101286
- tissue_or_cell_type
- Purified holo and apo protein
Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 788–799
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Crystallography, solution oligomers and biochemical assays · source_derived_draft · unverified_draft
### glutathione-glrx5-gsh-ligand Each GLRX5-bound [2Fe-2S] cluster was ligated by two protein Cys67 thiols and two GSH cysteine thiols. Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: Glutathione is part of the cluster-binding structure, not only an antioxidant. organism: Human GLRX5 tissue_or_cell_type: Purified holo and apo protein experimental_model: Crystallography, solution oligomers and biochemical assays limitations: The structural cluster complex is not a dietary-iron requirement or proof of supplement synergy. exposure: Iron-sulfur/GSH complex and disulfide assays evidence_span: {"source_cache": "artifacts/glutathione-research/21029046.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bc7e33127eee3685d1f90bff5a83334d68ac0ee3f73eeb67e4a9e189c5ba20b2", "start_char": 0, "end_char": 1468, "text_sha256": "bc7e33127eee3685d1f90bff5a83334d68ac0ee3f73eeb67e4a9e189c5ba20b2"} [glutathione-p21029046] The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity. (2011). https://pubmed.ncbi.nlm.nih.gov/21029046/ DOI: 10.1042/bj20101286
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.