Component
Human GLRX2-mediated protein deglutathionylation
Human GLRX2-mediated protein deglutathionylation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
GLRX2 reduced glutathionylated substrates with lower rate but higher affinity than GLRX1, giving similar catalytic efficiency.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/glutathione-research/14676218.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a7399b7d035bd3815c30362449b7986dea08873c824e05506d7db627a71daa84", "start_char": 0, "end_char": 1398, "text_sha256": "a7399b7d035bd3815c30362449b7986dea08873c824e05506d7db627a71daa84"}
- experimental_model
- Purified human glutaredoxin kinetics and mutants
- exposure
- GSH or NADPH/thioredoxin-reductase donor systems
- limitations
- Biochemical electron-donor alternatives; no claim that all cellular GLRX2 uses one route.
- nutrient_topic
- Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
- organism
- Human GLRX1/GLRX2
- plain_language
- Glutathione attached to a protein can be removed enzymatically.
- primary_references
- [glutathione-p14676218] Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase. (2004). https://pubmed.ncbi.nlm.nih.gov/14676218/ DOI: 10.1074/jbc.m312719200
- tissue_or_cell_type
- Glutathionylated substrates
Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 814–825
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human glutaredoxin kinetics and mutants · source_derived_draft · unverified_draft
### glutathione-glrx2-deglutathionylation GLRX2 reduced glutathionylated substrates with lower rate but higher affinity than GLRX1, giving similar catalytic efficiency. Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: Glutathione attached to a protein can be removed enzymatically. organism: Human GLRX1/GLRX2 tissue_or_cell_type: Glutathionylated substrates experimental_model: Purified human glutaredoxin kinetics and mutants limitations: Biochemical electron-donor alternatives; no claim that all cellular GLRX2 uses one route. exposure: GSH or NADPH/thioredoxin-reductase donor systems evidence_span: {"source_cache": "artifacts/glutathione-research/14676218.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a7399b7d035bd3815c30362449b7986dea08873c824e05506d7db627a71daa84", "start_char": 0, "end_char": 1398, "text_sha256": "a7399b7d035bd3815c30362449b7986dea08873c824e05506d7db627a71daa84"} [glutathione-p14676218] Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase. (2004). https://pubmed.ncbi.nlm.nih.gov/14676218/ DOI: 10.1074/jbc.m312719200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.