Component

Ginkgotoxin / 4-prime-O-methylpyridoxine

Ginkgotoxin / 4-prime-O-methylpyridoxine

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Human PDXK crystallography placed ginkgotoxin at the pyridoxal-binding site alongside MgATP.

    Ginkgotoxin / 4-prime-O-methylpyridoxine → Pyridoxal kinase / PDXK source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    experimental_model
    Purified human PDXK; crystallography and inhibition kinetics
    exposure
    2.15 angstrom ternary crystal structure.
    limitations
    Binding in a purified protein does not establish brain concentrations.
    nutrient_topic
    Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
    organism
    Homo sapiens
    plain_language
    The structure directly locates the competing toxin.
    primary_references
    [gandhi-2012-pdxk-inhibitors] Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition (2012). https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040954 DOI: 10.1371/journal.pone.0040954
    tissue_or_cell_type
    Purified recombinant protein; no intact tissue
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1208–1218

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human PDXK; crystallography and inhibition kinetics · source_derived_draft · unverified_draft

    ### b6-neuro-ginkgotoxin-binding Human PDXK crystallography placed ginkgotoxin at the pyridoxal-binding site alongside MgATP. Condition category: machinery_impairment nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The structure directly locates the competing toxin. organism: Homo sapiens tissue_or_cell_type: Purified recombinant protein; no intact tissue experimental_model: Purified human PDXK; crystallography and inhibition kinetics limitations: Binding in a purified protein does not establish brain concentrations. exposure: 2.15 angstrom ternary crystal structure. [gandhi-2012-pdxk-inhibitors] Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition (2012). https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040954 DOI: 10.1371/journal.pone.0040954
    Complete structured claim and evidence

  2. Ginkgotoxin competed with pyridoxal and delayed PLP formation by human PDXK; increasing pyridoxal alleviated inhibition.

    Ginkgotoxin / 4-prime-O-methylpyridoxine → Pyridoxal kinase / PDXK source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    experimental_model
    Purified recombinant human PDXK; HPLC and kinetic competition assays
    exposure
    25 micromolar pyridoxal with 12.5-25 micromolar ginkgotoxin in illustrative co-incubations.
    limitations
    Reported Ki was assay-specific; not a clinical exposure limit.
    nutrient_topic
    Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
    organism
    Homo sapiens
    plain_language
    The toxin competes for the enzyme that activates B6.
    primary_references
    [kastner-2007-ginkgotoxin] The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba (2007). https://doi.org/10.1111/j.1742-4658.2007.05654.x DOI: 10.1111/j.1742-4658.2007.05654.x
    tissue_or_cell_type
    Purified recombinant protein; no intact tissue
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1196–1206

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified recombinant human PDXK; HPLC and kinetic competition assays · source_derived_draft · unverified_draft

    ### b6-neuro-ginkgotoxin-plp-competition Ginkgotoxin competed with pyridoxal and delayed PLP formation by human PDXK; increasing pyridoxal alleviated inhibition. Condition category: machinery_impairment nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The toxin competes for the enzyme that activates B6. organism: Homo sapiens tissue_or_cell_type: Purified recombinant protein; no intact tissue experimental_model: Purified recombinant human PDXK; HPLC and kinetic competition assays limitations: Reported Ki was assay-specific; not a clinical exposure limit. exposure: 25 micromolar pyridoxal with 12.5-25 micromolar ginkgotoxin in illustrative co-incubations. [kastner-2007-ginkgotoxin] The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba (2007). https://doi.org/10.1111/j.1742-4658.2007.05654.x DOI: 10.1111/j.1742-4658.2007.05654.x
    Complete structured claim and evidence

What acts on it

  1. Purified human PDXK converted ginkgotoxin to its 5-prime-phosphate in an ATP-dependent assay.

    Pyridoxal kinase / PDXK → Ginkgotoxin / 4-prime-O-methylpyridoxine source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Purified recombinant human PDXK; HPLC and kinetic competition assays
    exposure
    HPLC product identification at 37 C, pH 6.2.
    limitations
    Purified-enzyme substrate recognition does not establish a whole-body toxicity threshold.
    nutrient_topic
    Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
    organism
    Homo sapiens
    plain_language
    The toxin can use the B6-activating enzyme.
    primary_references
    [kastner-2007-ginkgotoxin] The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba (2007). https://doi.org/10.1111/j.1742-4658.2007.05654.x DOI: 10.1111/j.1742-4658.2007.05654.x
    tissue_or_cell_type
    Purified recombinant protein; no intact tissue

    Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1184–1194

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified recombinant human PDXK; HPLC and kinetic competition assays · source_derived_draft · unverified_draft

    ### b6-neuro-ginkgotoxin-phosphorylation Purified human PDXK converted ginkgotoxin to its 5-prime-phosphate in an ATP-dependent assay. Condition category: normal nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The toxin can use the B6-activating enzyme. organism: Homo sapiens tissue_or_cell_type: Purified recombinant protein; no intact tissue experimental_model: Purified recombinant human PDXK; HPLC and kinetic competition assays limitations: Purified-enzyme substrate recognition does not establish a whole-body toxicity threshold. exposure: HPLC product identification at 37 C, pH 6.2. [kastner-2007-ginkgotoxin] The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba (2007). https://doi.org/10.1111/j.1742-4658.2007.05654.x DOI: 10.1111/j.1742-4658.2007.05654.x
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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