Component
GDC-0834
GDC-0834. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Inhibitor and fractionation experiments implicated AO and carboxylesterase, but not XOR, in GDC-0834 amide hydrolysis.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/molybdenum-research/25845827.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8f5a9632067829ecae57508a9127fb042a6467165c3fc494fdd44be975dadf40", "start_char": 0, "end_char": 1619, "text_sha256": "8f5a9632067829ecae57508a9127fb042a6467165c3fc494fdd44be975dadf40"}
- experimental_model
- Human liver cytosolic fractionation, proteomics, inhibitors and docking
- exposure
- GDC-0834 amide-hydrolysis assays
- limitations
- AO and carboxylesterase both implicated; docking proposes a mechanism but does not prove every catalytic step.
- nutrient_topic
- Molybdenum research collection; topical membership is not evidence of a direct dietary effect. · Molybdenum
- organism
- Homo sapiens
- plain_language
- AOX1 can participate in drug breakdown beyond simple aldehyde oxidation.
- primary_references
- [mo-p25845827] A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834. (2015). https://pubmed.ncbi.nlm.nih.gov/25845827/ DOI: 10.1124/dmd.114.061804
- tissue_or_cell_type
- Liver cytosol
Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17) · lines 924–935
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human liver cytosolic fractionation, proteomics, inhibitors and docking · source_derived_draft · unverified_draft
### mo-aox-amide Inhibitor and fractionation experiments implicated AO and carboxylesterase, but not XOR, in GDC-0834 amide hydrolysis. Condition category: normal nutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect. plain_language: AOX1 can participate in drug breakdown beyond simple aldehyde oxidation. organism: Homo sapiens tissue_or_cell_type: Liver cytosol experimental_model: Human liver cytosolic fractionation, proteomics, inhibitors and docking limitations: AO and carboxylesterase both implicated; docking proposes a mechanism but does not prove every catalytic step. exposure: GDC-0834 amide-hydrolysis assays evidence_span: {"source_cache": "artifacts/molybdenum-research/25845827.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8f5a9632067829ecae57508a9127fb042a6467165c3fc494fdd44be975dadf40", "start_char": 0, "end_char": 1619, "text_sha256": "8f5a9632067829ecae57508a9127fb042a6467165c3fc494fdd44be975dadf40"} [mo-p25845827] A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834. (2015). https://pubmed.ncbi.nlm.nih.gov/25845827/ DOI: 10.1124/dmd.114.061804
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.