Component
Brain-to-blood efflux transport of GABA
Brain-to-blood efflux transport of GABA. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Study of brain to blood efflux transport of carbon-14 GABA after loading the brain by vascular perfusion revealed that the half-time of elimination was significantly shorter in spontaneously hypertensive rats at 5.35 plus or minus 0.66 minutes than in Wistar Kyoto rats at 14.83 plus or minus 1.94 minutes, the faster efflux might at least partially compensate for increased uptake and preserve the protective function of the barrier towards GABA, and systemic infusion of GABA within a wide range of administered doses from 0.004 to 5.00 milligrams per kilogram produced an increase in cerebrospinal fluid GABA concentration from around 0.5 micromolar to only 11 micromolar.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/gaba-research/16616765.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "550c910f870ffc48b56fbcfe95555a4fec6441bdbef7b1369ef79d1bcba6df5d", "start_char": 0, "end_char": 1941, "text_sha256": "550c910f870ffc48b56fbcfe95555a4fec6441bdbef7b1369ef79d1bcba6df5d"}
- experimental_model
- In situ brain perfusion with efflux measurement and cerebrospinal fluid sampling across a range of systemic doses
- exposure
- Carbon-14 GABA by bilateral in situ brain perfusion, and systemic GABA infusion from 0.004 to 5.00 milligrams per kilogram
- limitations
- Anaesthetised rats, and the comparison is between hypertensive and normotensive strains. The dose-ranging cerebrospinal fluid measurement is the part that bears on oral supplementation.
- nutrient_topic
- GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. · Gamma-aminobutyric acid
- organism
- Rat
- plain_language
- The brain actively pumps this molecule back out, and flooding the bloodstream with it barely shifts the concentration inside.
- primary_references
- [gb-p16616765] Increased brain uptake and brain to blood efflux transport of 14C-GABA in spontaneously hypertensive rats. (2006). https://pubmed.ncbi.nlm.nih.gov/16616765/ DOI: 10.1016/j.lfs.2006.02.039
- tissue_or_cell_type
- Brain, cerebrospinal fluid and cerebral capillaries
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · In situ brain perfusion with efflux measurement and cerebrospinal fluid sampling across a range of systemic doses · source_derived_draft · unverified_draft
### gb-the-brain-pushes-gaba-back-out Study of brain to blood efflux transport of carbon-14 GABA after loading the brain by vascular perfusion revealed that the half-time of elimination was significantly shorter in spontaneously hypertensive rats at 5.35 plus or minus 0.66 minutes than in Wistar Kyoto rats at 14.83 plus or minus 1.94 minutes, the faster efflux might at least partially compensate for increased uptake and preserve the protective function of the barrier towards GABA, and systemic infusion of GABA within a wide range of administered doses from 0.004 to 5.00 milligrams per kilogram produced an increase in cerebrospinal fluid GABA concentration from around 0.5 micromolar to only 11 micromolar. Condition category: normal nutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. plain_language: The brain actively pumps this molecule back out, and flooding the bloodstream with it barely shifts the concentration inside. organism: Rat tissue_or_cell_type: Brain, cerebrospinal fluid and cerebral capillaries experimental_model: In situ brain perfusion with efflux measurement and cerebrospinal fluid sampling across a range of systemic doses limitations: Anaesthetised rats, and the comparison is between hypertensive and normotensive strains. The dose-ranging cerebrospinal fluid measurement is the part that bears on oral supplementation. exposure: Carbon-14 GABA by bilateral in situ brain perfusion, and systemic GABA infusion from 0.004 to 5.00 milligrams per kilogram evidence_span: {"source_cache": "artifacts/gaba-research/16616765.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "550c910f870ffc48b56fbcfe95555a4fec6441bdbef7b1369ef79d1bcba6df5d", "start_char": 0, "end_char": 1941, "text_sha256": "550c910f870ffc48b56fbcfe95555a4fec6441bdbef7b1369ef79d1bcba6df5d"} [gb-p16616765] Increased brain uptake and brain to blood efflux transport of 14C-GABA in spontaneously hypertensive rats. (2006). https://pubmed.ncbi.nlm.nih.gov/16616765/ DOI: 10.1016/j.lfs.2006.02.039
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.