Component
Tyrosine-protein kinase Fyn
Tyrosine-protein kinase Fyn. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Fyn kinase is a determinant of ethanol sensitivity through its relation to NMDA receptor function, with tyrosine phosphorylation of the receptor linked to acute tolerance.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/alcohol-research/9381182.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "008253b9262aee0b3acd845dfea4f9c087c00e0078bd1ba9b4eaa265192ec782", "start_char": 0, "end_char": 742, "text_sha256": "008253b9262aee0b3acd845dfea4f9c087c00e0078bd1ba9b4eaa265192ec782"}
- experimental_model
- Fyn-null mice with NMDA receptor phosphorylation measurement
- exposure
- Ethanol sensitivity and tyrosine phosphorylation in Fyn-deficient mice
- limitations
- Links acute tolerance to a specific kinase. The behavioural readout is hypnotic sensitivity, not drinking.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Mouse
- plain_language
- A kinase decides how quickly the receptor adapts, and so how quickly tolerance appears.
- primary_references
- [alcohol-p9381182] Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. (1997). https://pubmed.ncbi.nlm.nih.gov/9381182/ DOI: 10.1126/science.278.5338.698
- tissue_or_cell_type
- Hippocampus
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 306–317
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Fyn-null mice with NMDA receptor phosphorylation measurement · source_derived_draft · unverified_draft
### alcohol-fyn-tolerance Fyn kinase is a determinant of ethanol sensitivity through its relation to NMDA receptor function, with tyrosine phosphorylation of the receptor linked to acute tolerance. Condition category: machinery_impairment nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: A kinase decides how quickly the receptor adapts, and so how quickly tolerance appears. organism: Mouse tissue_or_cell_type: Hippocampus experimental_model: Fyn-null mice with NMDA receptor phosphorylation measurement limitations: Links acute tolerance to a specific kinase. The behavioural readout is hypnotic sensitivity, not drinking. exposure: Ethanol sensitivity and tyrosine phosphorylation in Fyn-deficient mice evidence_span: {"source_cache": "artifacts/alcohol-research/9381182.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "008253b9262aee0b3acd845dfea4f9c087c00e0078bd1ba9b4eaa265192ec782", "start_char": 0, "end_char": 742, "text_sha256": "008253b9262aee0b3acd845dfea4f9c087c00e0078bd1ba9b4eaa265192ec782"} [alcohol-p9381182] Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. (1997). https://pubmed.ncbi.nlm.nih.gov/9381182/ DOI: 10.1126/science.278.5338.698
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.