Component
O-glycosylated FGF23 in the FAM20C processing study
O-glycosylated FGF23 in the FAM20C processing study. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Ser180 phosphorylation inhibited GalNAc-T3-mediated O-glycosylation of FGF23.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/phosphorus-research/24706917.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7ccd1d1a23c74c980009e67ac6b0feafa3c30c28a99d8b240bef93bcc4cf29be", "start_char": 0, "end_char": 1346, "text_sha256": "7ccd1d1a23c74c980009e67ac6b0feafa3c30c28a99d8b240bef93bcc4cf29be"}
- experimental_model
- Recombinant processing and phosphorylation/glycosylation experiments
- exposure
- FAM20C, GalNAc-T3 and furin manipulation
- limitations
- Protein-modification control, not a claim that dietary phosphate directly phosphorylates FGF23. Construct scope is retained rather than assigning every result to intact human physiology.
- nutrient_topic
- Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
- organism
- Construct system; precise species not inferred from abstract
- plain_language
- The phosphate mark interfered with a competing sugar modification.
- primary_references
- [phosphorus-p24706917] Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. (2014). https://pubmed.ncbi.nlm.nih.gov/24706917/ DOI: 10.1073/pnas.1402218111
- tissue_or_cell_type
- Secretory protein processing
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 503–514
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant processing and phosphorylation/glycosylation experiments · source_derived_draft · unverified_draft
### phosphorus-fgf23-glycosylation Ser180 phosphorylation inhibited GalNAc-T3-mediated O-glycosylation of FGF23. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The phosphate mark interfered with a competing sugar modification. organism: Construct system; precise species not inferred from abstract tissue_or_cell_type: Secretory protein processing experimental_model: Recombinant processing and phosphorylation/glycosylation experiments limitations: Protein-modification control, not a claim that dietary phosphate directly phosphorylates FGF23. Construct scope is retained rather than assigning every result to intact human physiology. exposure: FAM20C, GalNAc-T3 and furin manipulation evidence_span: {"source_cache": "artifacts/phosphorus-research/24706917.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7ccd1d1a23c74c980009e67ac6b0feafa3c30c28a99d8b240bef93bcc4cf29be", "start_char": 0, "end_char": 1346, "text_sha256": "7ccd1d1a23c74c980009e67ac6b0feafa3c30c28a99d8b240bef93bcc4cf29be"} [phosphorus-p24706917] Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. (2014). https://pubmed.ncbi.nlm.nih.gov/24706917/ DOI: 10.1073/pnas.1402218111
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.