Component
A fall in forced expiratory volume in one second
A fall in forced expiratory volume in one second. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Three aspirin-sensitive asthmatic subjects with a history of reactions underwent double-blind placebo-controlled challenges and reacted to 1000 milligrams of acetaminophen with a greater than 20% fall in forced expiratory volume in one second, two were desensitized to aspirin and then rechallenged with 1000 milligrams of acetaminophen without reaction, and two were desensitized to acetaminophen achieving refractoriness to 1500 but not 2000 milligrams, so cross sensitivity was documented at large challenge doses and the cross desensitization suggests similar mechanisms are responsible for reactions to aspirin, non-steroidal anti-inflammatory drugs and acetaminophen.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/paracetamol-research/2666482.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9c731e77d65955b683aa03e7df1252729e11b1fb8bed714b9138f22c725eac2b", "start_char": 0, "end_char": 1081, "text_sha256": "9c731e77d65955b683aa03e7df1252729e11b1fb8bed714b9138f22c725eac2b"}
- experimental_model
- Double-blind placebo-controlled oral challenge and desensitisation in three aspirin-sensitive asthmatic subjects
- exposure
- 1000 to 2000 milligram acetaminophen challenges, with aspirin desensitisation and acetaminophen desensitisation
- limitations
- Three subjects, selected for a history of reacting, so the frequency of cross-reactivity cannot be read from it. The cross-desensitisation result is what identifies the shared mechanism.
- nutrient_topic
- Paracetamol research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from the metabolites NAPQI and AM404. · Paracetamol
- organism
- Human
- plain_language
- Desensitise the patient to aspirin and they stop reacting to paracetamol, so it is the same mechanism at work.
- primary_references
- [apap-p2666482] Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma. (1989). https://pubmed.ncbi.nlm.nih.gov/2666482/ DOI: 10.1016/0091-6749(89)90174-7
- tissue_or_cell_type
- Airway
- trigger_kind
- biomarker_context Imported condition classification; unverified.
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind placebo-controlled oral challenge and desensitisation in three aspirin-sensitive asthmatic subjects · source_derived_draft · unverified_draft
### apap-cross-desensitisation-shows-shared-mechanism Three aspirin-sensitive asthmatic subjects with a history of reactions underwent double-blind placebo-controlled challenges and reacted to 1000 milligrams of acetaminophen with a greater than 20% fall in forced expiratory volume in one second, two were desensitized to aspirin and then rechallenged with 1000 milligrams of acetaminophen without reaction, and two were desensitized to acetaminophen achieving refractoriness to 1500 but not 2000 milligrams, so cross sensitivity was documented at large challenge doses and the cross desensitization suggests similar mechanisms are responsible for reactions to aspirin, non-steroidal anti-inflammatory drugs and acetaminophen. Condition category: biomarker_context nutrient_topic: Paracetamol research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from the metabolites NAPQI and AM404. plain_language: Desensitise the patient to aspirin and they stop reacting to paracetamol, so it is the same mechanism at work. organism: Human tissue_or_cell_type: Airway experimental_model: Double-blind placebo-controlled oral challenge and desensitisation in three aspirin-sensitive asthmatic subjects limitations: Three subjects, selected for a history of reacting, so the frequency of cross-reactivity cannot be read from it. The cross-desensitisation result is what identifies the shared mechanism. exposure: 1000 to 2000 milligram acetaminophen challenges, with aspirin desensitisation and acetaminophen desensitisation evidence_span: {"source_cache": "artifacts/paracetamol-research/2666482.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9c731e77d65955b683aa03e7df1252729e11b1fb8bed714b9138f22c725eac2b", "start_char": 0, "end_char": 1081, "text_sha256": "9c731e77d65955b683aa03e7df1252729e11b1fb8bed714b9138f22c725eac2b"} [apap-p2666482] Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma. (1989). https://pubmed.ncbi.nlm.nih.gov/2666482/ DOI: 10.1016/0091-6749(89)90174-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.