Component
Plasma fenofibrate exposure
Plasma fenofibrate exposure. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
No clinically obvious pharmacokinetic interaction with fenofibrate was detected in the tested berberine-chloride combination regimen.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/berberine-research/30587933.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f82b466cc2942fd70940935e1fa42174f135036017a589bc7fa86388e6f9e4be", "start_char": 0, "end_char": 2118, "text_sha256": "f82b466cc2942fd70940935e1fa42174f135036017a589bc7fa86388e6f9e4be"}
- experimental_model
- Open-label randomized parallel pharmacokinetic study
- exposure
- Single-dose and seven-day repeated treatment; berberine chloride alone or combined
- limitations
- Short, small healthy-volunteer study. Absence of an obvious interaction here does not establish unrestricted long-term safety in patients.
- nutrient_topic
- Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
- organism
- Sixty healthy Chinese participants across five groups
- plain_language
- The measured result limits a blanket claim that every relevant drug concentration must rise.
- primary_references
- [berberine-p30587933] Pharmacokinetic interactions and tolerability of berberine chloride with simvastatin and fenofibrate: an open-label, randomized, parallel study in healthy Chinese subjects. (2019). https://pubmed.ncbi.nlm.nih.gov/30587933/ DOI: 10.2147/dddt.s185487
- tissue_or_cell_type
- Simvastatin and fenofibrate exposure
Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 948–959
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Open-label randomized parallel pharmacokinetic study · source_derived_draft · unverified_draft
### berberine-clinical-fibrate-null No clinically obvious pharmacokinetic interaction with fenofibrate was detected in the tested berberine-chloride combination regimen. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The measured result limits a blanket claim that every relevant drug concentration must rise. organism: Sixty healthy Chinese participants across five groups tissue_or_cell_type: Simvastatin and fenofibrate exposure experimental_model: Open-label randomized parallel pharmacokinetic study limitations: Short, small healthy-volunteer study. Absence of an obvious interaction here does not establish unrestricted long-term safety in patients. exposure: Single-dose and seven-day repeated treatment; berberine chloride alone or combined evidence_span: {"source_cache": "artifacts/berberine-research/30587933.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f82b466cc2942fd70940935e1fa42174f135036017a589bc7fa86388e6f9e4be", "start_char": 0, "end_char": 2118, "text_sha256": "f82b466cc2942fd70940935e1fa42174f135036017a589bc7fa86388e6f9e4be"} [berberine-p30587933] Pharmacokinetic interactions and tolerability of berberine chloride with simvastatin and fenofibrate: an open-label, randomized, parallel study in healthy Chinese subjects. (2019). https://pubmed.ncbi.nlm.nih.gov/30587933/ DOI: 10.2147/dddt.s185487
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.