Component
Femoral neck bone mineral density
Femoral neck bone mineral density. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
MK-7 reduced age-related loss of lumbar-spine and femoral-neck BMD/BMC, but not total-hip BMD, over three years.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/k2-research/23525894.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a3ce7b3935f14513cb967410370b1bca786c7548989964d658077108e362f4dc", "start_char": 0, "end_char": 2060, "text_sha256": "a3ce7b3935f14513cb967410370b1bca786c7548989964d658077108e362f4dc"}
- experimental_model
- Three-year double-blind placebo-controlled trial
- exposure
- MK-7 180 micrograms/day
- limitations
- Site-specific surrogate outcomes; not proof of fracture prevention in every population. The arterial-stiffness publication describes the same cohort.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- 244 healthy postmenopausal women
- plain_language
- The result differed by skeletal site.
- primary_references
- [k2-p23525894] Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. (2013). https://pubmed.ncbi.nlm.nih.gov/23525894/ DOI: 10.1007/s00198-013-2325-6
- tissue_or_cell_type
- DXA and osteocalcin markers
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1072–1083
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Three-year double-blind placebo-controlled trial · source_derived_draft · unverified_draft
### k2-mk7-bone-positive MK-7 reduced age-related loss of lumbar-spine and femoral-neck BMD/BMC, but not total-hip BMD, over three years. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The result differed by skeletal site. organism: 244 healthy postmenopausal women tissue_or_cell_type: DXA and osteocalcin markers experimental_model: Three-year double-blind placebo-controlled trial limitations: Site-specific surrogate outcomes; not proof of fracture prevention in every population. The arterial-stiffness publication describes the same cohort. exposure: MK-7 180 micrograms/day evidence_span: {"source_cache": "artifacts/k2-research/23525894.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a3ce7b3935f14513cb967410370b1bca786c7548989964d658077108e362f4dc", "start_char": 0, "end_char": 2060, "text_sha256": "a3ce7b3935f14513cb967410370b1bca786c7548989964d658077108e362f4dc"} [k2-p23525894] Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. (2013). https://pubmed.ncbi.nlm.nih.gov/23525894/ DOI: 10.1007/s00198-013-2325-6
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.