Component
Self-reported fatigue severity
Self-reported fatigue severity. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Fatigue scores decreased 47.7% with iron versus 28.8% with placebo; the between-group difference was significant (P=0.02).
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/iron-research/22777991.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d8d360cee2d71d5cf1d7b19bbd5c740164d24c16daf98fe4519551573f8fb75", "start_char": 0, "end_char": 1708, "text_sha256": "7d8d360cee2d71d5cf1d7b19bbd5c740164d24c16daf98fe4519551573f8fb75"}
- experimental_model
- Randomized placebo-controlled 12-week trial
- exposure
- Ferritin below 50 micrograms/L, hemoglobin above 12 g/dL; 80 mg elemental iron/day versus placebo
- limitations
- Trial inclusion criteria are not a universal deficiency threshold. No significant improvement in depression, anxiety or overall quality of life.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- 198 nonanemic menstruating women with fatigue
- plain_language
- Normal-range hemoglobin did not exclude an iron-responsive fatigue outcome in this selected group.
- primary_references
- [iron-p22777991] Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial. (2012). https://pubmed.ncbi.nlm.nih.gov/22777991/ DOI: 10.1503/cmaj.110950
- tissue_or_cell_type
- Reported symptoms and blood markers
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 1317–1328
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled 12-week trial · source_derived_draft · unverified_draft
### iron-nonanemic-fatigue Fatigue scores decreased 47.7% with iron versus 28.8% with placebo; the between-group difference was significant (P=0.02). Condition category: biomarker_context nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Normal-range hemoglobin did not exclude an iron-responsive fatigue outcome in this selected group. organism: 198 nonanemic menstruating women with fatigue tissue_or_cell_type: Reported symptoms and blood markers experimental_model: Randomized placebo-controlled 12-week trial limitations: Trial inclusion criteria are not a universal deficiency threshold. No significant improvement in depression, anxiety or overall quality of life. exposure: Ferritin below 50 micrograms/L, hemoglobin above 12 g/dL; 80 mg elemental iron/day versus placebo evidence_span: {"source_cache": "artifacts/iron-research/22777991.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d8d360cee2d71d5cf1d7b19bbd5c740164d24c16daf98fe4519551573f8fb75", "start_char": 0, "end_char": 1708, "text_sha256": "7d8d360cee2d71d5cf1d7b19bbd5c740164d24c16daf98fe4519551573f8fb75"} [iron-p22777991] Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial. (2012). https://pubmed.ncbi.nlm.nih.gov/22777991/ DOI: 10.1503/cmaj.110950
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.