Component
Ex vivo cytokine production by stimulated leukocytes
Ex vivo cytokine production by stimulated leukocytes. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In a randomised open-label intervention pilot study in 15 healthy male volunteers, subjects in the beta-glucan group ingested beta-glucan 1000 milligrams once daily for 7 days, beta-glucan was barely detectable in serum of volunteers at all time-points, and neither cytokine production nor microbicidal activity of leukocytes were affected by orally administered beta-glucan, so the present study does not support the use of oral beta-glucan to enhance innate immune responses in humans.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/glucan-research/25268806.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b5a583c465284aae8e7d3e6dd9996fafe3b6ef389c61ee2a54f066fb4701e51b", "start_char": 0, "end_char": 1307, "text_sha256": "b5a583c465284aae8e7d3e6dd9996fafe3b6ef389c61ee2a54f066fb4701e51b"}
- experimental_model
- Randomised open-label intervention pilot study in 15 healthy male volunteers
- exposure
- Oral beta-glucan 1000 milligrams once daily for 7 days against no treatment, with serial sampling
- limitations
- Ten treated and five control subjects, one product, one dose, seven days, and ex vivo readouts. A negative pilot of this size does not establish that all oral preparations are inactive.
- nutrient_topic
- Beta-glucan research collection; topical membership is not evidence of a direct clinical effect, and each preparation is recorded as its own entity with no family link joining any pair. · Beta-glucan
- organism
- Human
- plain_language
- Ten healthy men took a gram a day for a week; almost none of it showed up in the blood and nothing measurable changed.
- primary_references
- [bg-p25268806] The effects of orally administered Beta-glucan on innate immune responses in humans, a randomized open-label intervention pilot-study. (2014). https://pubmed.ncbi.nlm.nih.gov/25268806/ DOI: 10.1371/journal.pone.0108794
- tissue_or_cell_type
- Serum and peripheral leukocytes
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomised open-label intervention pilot study in 15 healthy male volunteers · source_derived_draft · unverified_draft
### bg-in-people-nothing-was-detectable In a randomised open-label intervention pilot study in 15 healthy male volunteers, subjects in the beta-glucan group ingested beta-glucan 1000 milligrams once daily for 7 days, beta-glucan was barely detectable in serum of volunteers at all time-points, and neither cytokine production nor microbicidal activity of leukocytes were affected by orally administered beta-glucan, so the present study does not support the use of oral beta-glucan to enhance innate immune responses in humans. Condition category: normal nutrient_topic: Beta-glucan research collection; topical membership is not evidence of a direct clinical effect, and each preparation is recorded as its own entity with no family link joining any pair. plain_language: Ten healthy men took a gram a day for a week; almost none of it showed up in the blood and nothing measurable changed. organism: Human tissue_or_cell_type: Serum and peripheral leukocytes experimental_model: Randomised open-label intervention pilot study in 15 healthy male volunteers limitations: Ten treated and five control subjects, one product, one dose, seven days, and ex vivo readouts. A negative pilot of this size does not establish that all oral preparations are inactive. exposure: Oral beta-glucan 1000 milligrams once daily for 7 days against no treatment, with serial sampling evidence_span: {"source_cache": "artifacts/glucan-research/25268806.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b5a583c465284aae8e7d3e6dd9996fafe3b6ef389c61ee2a54f066fb4701e51b", "start_char": 0, "end_char": 1307, "text_sha256": "b5a583c465284aae8e7d3e6dd9996fafe3b6ef389c61ee2a54f066fb4701e51b"} [bg-p25268806] The effects of orally administered Beta-glucan on innate immune responses in humans, a randomized open-label intervention pilot-study. (2014). https://pubmed.ncbi.nlm.nih.gov/25268806/ DOI: 10.1371/journal.pone.0108794
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.