Component
SIRT1 inhibition or SIRT6 silencing in endothelial assay
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
SIRT1 activity inhibition or SIRT6 siRNA abolished ergothioneine protection against high-glucose-induced endothelial senescence.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Endothelial-cell pharmacological and genetic perturbation.
- limitations
- Dependence is stronger than expression association, but does not show direct binding or supply of NAD.
- nutrient_topic
- Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
- plain_language
- Blocking the regulatory machinery removed protection.
- primary_references
- Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27101740/ · DOI 10.1016/j.freeradbiomed.2016.04.013
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 360–366
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Endothelial-cell pharmacological and genetic perturbation. · source_derived_draft · unverified_draft
## ergothioneine-sirtuin-dependence Blocking the regulatory machinery removed protection. SIRT1 activity inhibition or SIRT6 siRNA abolished ergothioneine protection against high-glucose-induced endothelial senescence. Model: Endothelial-cell pharmacological and genetic perturbation. Limitations: Dependence is stronger than expression association, but does not show direct binding or supply of NAD. Evidence access: Primary abstract Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27101740/ · DOI 10.1016/j.freeradbiomed.2016.04.013
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.