Component

Vascular endothelial cell

Vascular endothelial cell. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Treatment promoted expression of HIF-1alpha, NF-kappaB, VEGFA, SDF-1, VEGFR2 and CXCR4, with SDF-1 and VEGFA rising in human skin fibroblasts and CXCR4 and VEGFR2 rising in endothelial cells.

    Hyperbaric oxygen therapy → Stromal cell-derived factor 1 / SDF-1alpha / CXCL12 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/hbot-research/32791151.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "106ed876131af9161051c4c178d88af4afd707a20e56a91447d35aa9ed290188", "start_char": 0, "end_char": 1662, "text_sha256": "106ed876131af9161051c4c178d88af4afd707a20e56a91447d35aa9ed290188"}
    experimental_model
    Diabetic foot mouse model with human skin fibroblasts and human umbilical vein endothelial cells
    exposure
    Hyperbaric oxygen with high glucose in vitro
    limitations
    Cell and mouse work with expression endpoints. Tube formation is an angiogenesis surrogate, not a vessel in a person.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Mouse and human cells
    plain_language
    The signal and its receptor go up on two different cell types at once, which is what lets them find each other.
    primary_references
    [hbot-p32791151] Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis. (2020). https://pubmed.ncbi.nlm.nih.gov/32791151/ DOI: 10.1016/j.lfs.2020.118246
    tissue_or_cell_type
    Skin wound, fibroblasts and endothelium

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 660–671

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Diabetic foot mouse model with human skin fibroblasts and human umbilical vein endothelial cells · source_derived_draft · unverified_draft

    ### hbot-hif-vegf-sdf-axis Treatment promoted expression of HIF-1alpha, NF-kappaB, VEGFA, SDF-1, VEGFR2 and CXCR4, with SDF-1 and VEGFA rising in human skin fibroblasts and CXCR4 and VEGFR2 rising in endothelial cells. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The signal and its receptor go up on two different cell types at once, which is what lets them find each other. organism: Mouse and human cells tissue_or_cell_type: Skin wound, fibroblasts and endothelium experimental_model: Diabetic foot mouse model with human skin fibroblasts and human umbilical vein endothelial cells limitations: Cell and mouse work with expression endpoints. Tube formation is an angiogenesis surrogate, not a vessel in a person. exposure: Hyperbaric oxygen with high glucose in vitro evidence_span: {"source_cache": "artifacts/hbot-research/32791151.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "106ed876131af9161051c4c178d88af4afd707a20e56a91447d35aa9ed290188", "start_char": 0, "end_char": 1662, "text_sha256": "106ed876131af9161051c4c178d88af4afd707a20e56a91447d35aa9ed290188"} [hbot-p32791151] Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis. (2020). https://pubmed.ncbi.nlm.nih.gov/32791151/ DOI: 10.1016/j.lfs.2020.118246
    Complete structured claim and evidence

  2. Induction of ICAM-1 required simultaneous hypoxia and hypoglycaemia, and hyperbaric oxygen reduced its expression to control levels.

    Hyperbaric oxygen therapy → Intercellular adhesion molecule 1 / ICAM-1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/hbot-research/10666024.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9bb8781cab37af1af9f292e4611c19f273de986e86be681a357058d2cfb87ad8", "start_char": 0, "end_char": 1182, "text_sha256": "9bb8781cab37af1af9f292e4611c19f273de986e86be681a357058d2cfb87ad8"}
    experimental_model
    Human umbilical vein and bovine aortic endothelial cells in an in vitro ischaemia-reperfusion model
    exposure
    Hyperbaric oxygen after combined hypoxia and hypoglycaemia; L-NAME
    limitations
    An in vitro model requiring both hypoxia and hypoglycaemia to induce the adhesion molecule. The nitric oxide synthase inhibitor arm supports the proposed route.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Human and bovine cells
    plain_language
    The treatment switched off the docking molecule that inflamed vessels put out.
    primary_references
    [hbot-p10666024] Hyperbaric oxygen downregulates ICAM-1 expression induced by hypoxia and hypoglycemia: the role of NOS. (2000). https://pubmed.ncbi.nlm.nih.gov/10666024/ DOI: 10.1152/ajpcell.2000.278.2.c292
    tissue_or_cell_type
    Vascular endothelium

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 712–723

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human umbilical vein and bovine aortic endothelial cells in an in vitro ischaemia-reperfusion model · source_derived_draft · unverified_draft

    ### hbot-icam1-downregulation Induction of ICAM-1 required simultaneous hypoxia and hypoglycaemia, and hyperbaric oxygen reduced its expression to control levels. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The treatment switched off the docking molecule that inflamed vessels put out. organism: Human and bovine cells tissue_or_cell_type: Vascular endothelium experimental_model: Human umbilical vein and bovine aortic endothelial cells in an in vitro ischaemia-reperfusion model limitations: An in vitro model requiring both hypoxia and hypoglycaemia to induce the adhesion molecule. The nitric oxide synthase inhibitor arm supports the proposed route. exposure: Hyperbaric oxygen after combined hypoxia and hypoglycaemia; L-NAME evidence_span: {"source_cache": "artifacts/hbot-research/10666024.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9bb8781cab37af1af9f292e4611c19f273de986e86be681a357058d2cfb87ad8", "start_char": 0, "end_char": 1182, "text_sha256": "9bb8781cab37af1af9f292e4611c19f273de986e86be681a357058d2cfb87ad8"} [hbot-p10666024] Hyperbaric oxygen downregulates ICAM-1 expression induced by hypoxia and hypoglycemia: the role of NOS. (2000). https://pubmed.ncbi.nlm.nih.gov/10666024/ DOI: 10.1152/ajpcell.2000.278.2.c292
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards