Component
Endogenous oxalate synthesis
Independent measured endpoint or substance; model, assay and exposure are retained in each linked finding.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Within the responder subset, estimated endogenous oxalate synthesis was 544 versus 391 micromol/day with versus without supplementation.
Experimental context and source evidence
- experimental_model
- Randomized controlled-diet crossover study: 29 calcium stone formers and 19 non-stone formers.
- exposure
- Ascorbic acid 1000 mg twice daily for six days versus no supplement for six days; 13C2 oxalate challenge after adaptation.
- limitations
- Selected subgroup and short exposure; does not identify every enzymatic or nonenzymatic conversion step.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Homo sapiens
- plain_language
- The tracer-based analysis separated oxalate made within the body from oxalate absorbed from the test diet.
- primary_references
- [c-massey2005] Ascorbate increases human oxaluria and kidney stone risk (2005). https://pubmed.ncbi.nlm.nih.gov/15987848/ DOI: 10.1093/jn/135.7.1673
- tissue_or_cell_type
- Human blood or whole-person endpoints
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1658–1668
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized controlled-diet crossover study: 29 calcium stone formers and 19 non-stone formers. · source_derived_draft · unverified_draft
### c-high-oral-dose-oxalate-synthesis Within the responder subset, estimated endogenous oxalate synthesis was 544 versus 391 micromol/day with versus without supplementation. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: The tracer-based analysis separated oxalate made within the body from oxalate absorbed from the test diet. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Randomized controlled-diet crossover study: 29 calcium stone formers and 19 non-stone formers. limitations: Selected subgroup and short exposure; does not identify every enzymatic or nonenzymatic conversion step. exposure: Ascorbic acid 1000 mg twice daily for six days versus no supplement for six days; 13C2 oxalate challenge after adaptation. [c-massey2005] Ascorbate increases human oxaluria and kidney stone risk (2005). https://pubmed.ncbi.nlm.nih.gov/15987848/ DOI: 10.1093/jn/135.7.1673
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.