Component
Endogenous copper excretion
Endogenous copper excretion. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Endogenous copper losses increased from about 0.45 to 0.81 to 2.46 mg/day across the low, medium and high copper-intake conditions.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/copper-research/12844388.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5b6c40ba96ca6bba0b6d377caf643f3aebba366919c889e2e8f10be4b23a0def", "start_char": 0, "end_char": 1336, "text_sha256": "5b6c40ba96ca6bba0b6d377caf643f3aebba366919c889e2e8f10be4b23a0def"}
- experimental_model
- Controlled copper intake and stable-isotope balance study
- exposure
- Twelve men; 0.7, 1.6 or 6 mg/day intake periods with an oral 3 mg isotope challenge
- limitations
- The isotope challenge was the same at each dietary background. Similar fractional absorption under this test does not mean copper absorption is invariant at every dose.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Human men
- plain_language
- The body adjusted how much copper it removed.
- primary_references
- [copper-p12844388] Adaptive responses in men fed low- and high-copper diets. (2003). https://pubmed.ncbi.nlm.nih.gov/12844388/ DOI: 10.1079/bjn2003887
- tissue_or_cell_type
- Whole-body copper handling
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 1365–1376
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled copper intake and stable-isotope balance study · source_derived_draft · unverified_draft
### copper-copper-excretion-adaptation Endogenous copper losses increased from about 0.45 to 0.81 to 2.46 mg/day across the low, medium and high copper-intake conditions. Condition category: normal nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: The body adjusted how much copper it removed. organism: Human men tissue_or_cell_type: Whole-body copper handling experimental_model: Controlled copper intake and stable-isotope balance study limitations: The isotope challenge was the same at each dietary background. Similar fractional absorption under this test does not mean copper absorption is invariant at every dose. exposure: Twelve men; 0.7, 1.6 or 6 mg/day intake periods with an oral 3 mg isotope challenge evidence_span: {"source_cache": "artifacts/copper-research/12844388.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5b6c40ba96ca6bba0b6d377caf643f3aebba366919c889e2e8f10be4b23a0def", "start_char": 0, "end_char": 1336, "text_sha256": "5b6c40ba96ca6bba0b6d377caf643f3aebba366919c889e2e8f10be4b23a0def"} [copper-p12844388] Adaptive responses in men fed low- and high-copper diets. (2003). https://pubmed.ncbi.nlm.nih.gov/12844388/ DOI: 10.1079/bjn2003887
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.