Component
Hatching of nematode eggs
Hatching of nematode eggs. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Benzimidazole carbamates with strong inhibitory activity against mammalian tubulin were potent inhibitors of Haemonchus contortus egg hatch while non-inhibitors failed to prevent hatching, supporting the view that the primary mode of action of these drugs on nematode eggs is inhibition of microtubule-dependent processes within the developing egg.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mebendazole-research/3564338.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "89495a42e9f41cac9010e20e925b802c27fde1dfac9a4a24dd2236335f4d61b1", "start_char": 0, "end_char": 818, "text_sha256": "89495a42e9f41cac9010e20e925b802c27fde1dfac9a4a24dd2236335f4d61b1"}
- experimental_model
- Correlation of Haemonchus contortus egg hatch inhibition with inhibition of mammalian tubulin polymerisation
- exposure
- Benzimidazole carbamates tested in both assays
- limitations
- A correlation rather than a demonstration of mechanism in the egg, and the hatch assay was sensitive to co-solvent concentration and incubation time.
- nutrient_topic
- Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
- organism
- Nematode and mammal
- plain_language
- The compounds that block tubulin are the ones that stop eggs hatching, and the ones that do not, do not.
- primary_references
- [mbz-p3564338] Comparison of inhibition of polymerisation of mammalian tubulin and helminth ovicidal activity by benzimidazole carbamates. (1987). https://pubmed.ncbi.nlm.nih.gov/3564338/ DOI: 10.1016/0304-4017(87)90029-x
- tissue_or_cell_type
- Nematode eggs and mammalian tubulin
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Correlation of Haemonchus contortus egg hatch inhibition with inhibition of mammalian tubulin polymerisation · source_derived_draft · unverified_draft
### mbz-egg-hatch-tracks-tubulin Benzimidazole carbamates with strong inhibitory activity against mammalian tubulin were potent inhibitors of Haemonchus contortus egg hatch while non-inhibitors failed to prevent hatching, supporting the view that the primary mode of action of these drugs on nematode eggs is inhibition of microtubule-dependent processes within the developing egg. Condition category: normal nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: The compounds that block tubulin are the ones that stop eggs hatching, and the ones that do not, do not. organism: Nematode and mammal tissue_or_cell_type: Nematode eggs and mammalian tubulin experimental_model: Correlation of Haemonchus contortus egg hatch inhibition with inhibition of mammalian tubulin polymerisation limitations: A correlation rather than a demonstration of mechanism in the egg, and the hatch assay was sensitive to co-solvent concentration and incubation time. exposure: Benzimidazole carbamates tested in both assays evidence_span: {"source_cache": "artifacts/mebendazole-research/3564338.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "89495a42e9f41cac9010e20e925b802c27fde1dfac9a4a24dd2236335f4d61b1", "start_char": 0, "end_char": 818, "text_sha256": "89495a42e9f41cac9010e20e925b802c27fde1dfac9a4a24dd2236335f4d61b1"} [mbz-p3564338] Comparison of inhibition of polymerisation of mammalian tubulin and helminth ovicidal activity by benzimidazole carbamates. (1987). https://pubmed.ncbi.nlm.nih.gov/3564338/ DOI: 10.1016/0304-4017(87)90029-x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.