Component
Patency of the ductus arteriosus
Patency of the ductus arteriosus. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
At low oxygen tension ibuprofen produced a dose-dependent contraction of isolated lamb ductus arteriosus strips at all gestational ages and enhanced the potassium-induced contraction of the immature ductus, both effects being relatively greater in the 103 to 107 day group where ibuprofen also potentiated the oxygen-induced contraction, confirming that a prostaglandin is involved in ductus patency and indicating that the prostaglandin-relaxing mechanism becomes functional at an early stage of gestation and reaches maximal activity before term.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/ibuprofen-research/497895.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9d0874e6d05ee46097aeebdc1f0b9024541aa1305a648d6b783c329108a0bf0f", "start_char": 0, "end_char": 1229, "text_sha256": "9d0874e6d05ee46097aeebdc1f0b9024541aa1305a648d6b783c329108a0bf0f"}
- experimental_model
- Circular strips of lamb ductus arteriosus from 90 to 144 days gestation studied in vitro at low and high oxygen tension
- exposure
- Ibuprofen applied at low oxygen tension across gestational ages, with potassium and oxygen contractions
- limitations
- An isolated tissue study across a developmental range, which is what reveals that the prostaglandin brake matures before term. In vitro strips rather than a treated infant.
- nutrient_topic
- Ibuprofen research collection; topical membership is not evidence of a direct clinical effect, and the racemate is recorded separately from each of its two enantiomers. · Ibuprofen
- organism
- Lamb
- plain_language
- Blocking prostaglandins closes the vessel that has to close at birth, which is why the drug is used for that on purpose.
- primary_references
- [ibu-p497895] Age-dependent changes in the response of the lamb ductus arteriosus to oxygen and ibuprofen. (1979). https://pubmed.ncbi.nlm.nih.gov/497895/ DOI: 10.1139/y79-126
- tissue_or_cell_type
- Ductus arteriosus
- trigger_kind
- biomarker_context Imported condition classification; unverified.
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Circular strips of lamb ductus arteriosus from 90 to 144 days gestation studied in vitro at low and high oxygen tension · source_derived_draft · unverified_draft
### ibu-closes-the-ductus At low oxygen tension ibuprofen produced a dose-dependent contraction of isolated lamb ductus arteriosus strips at all gestational ages and enhanced the potassium-induced contraction of the immature ductus, both effects being relatively greater in the 103 to 107 day group where ibuprofen also potentiated the oxygen-induced contraction, confirming that a prostaglandin is involved in ductus patency and indicating that the prostaglandin-relaxing mechanism becomes functional at an early stage of gestation and reaches maximal activity before term. Condition category: biomarker_context nutrient_topic: Ibuprofen research collection; topical membership is not evidence of a direct clinical effect, and the racemate is recorded separately from each of its two enantiomers. plain_language: Blocking prostaglandins closes the vessel that has to close at birth, which is why the drug is used for that on purpose. organism: Lamb tissue_or_cell_type: Ductus arteriosus experimental_model: Circular strips of lamb ductus arteriosus from 90 to 144 days gestation studied in vitro at low and high oxygen tension limitations: An isolated tissue study across a developmental range, which is what reveals that the prostaglandin brake matures before term. In vitro strips rather than a treated infant. exposure: Ibuprofen applied at low oxygen tension across gestational ages, with potassium and oxygen contractions evidence_span: {"source_cache": "artifacts/ibuprofen-research/497895.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9d0874e6d05ee46097aeebdc1f0b9024541aa1305a648d6b783c329108a0bf0f", "start_char": 0, "end_char": 1229, "text_sha256": "9d0874e6d05ee46097aeebdc1f0b9024541aa1305a648d6b783c329108a0bf0f"} [ibu-p497895] Age-dependent changes in the response of the lamb ductus arteriosus to oxygen and ibuprofen. (1979). https://pubmed.ncbi.nlm.nih.gov/497895/ DOI: 10.1139/y79-126
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.