Component
Desferrioxamine
Iron-chelating experimental exposure; also called deferoxamine.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Desferrioxamine reduced beta-carotene-cleaving activity in human intestinal mucosa and TC7 cells.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Iron availability supports provitamin A cleavage in this in vitro model.
- evidence_location
- Abstract
- experimental_model
- Human small-intestinal mucosa and Caco-2 TC7 cells; desferrioxamine and iron addition.
- exposure
- Increasing desferrioxamine concentrations.
- limitations
- Drug-induced chelation; BCO1 protein abundance and human dietary deficiency were not directly established.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Homo sapiens
- outcome
- Desferrioxamine reduced beta-carotene-cleaving activity in human intestinal mucosa and TC7 cells.
- plain_language
- Sequestering iron limited conversion of provitamin A to retinal.
- primary_references
- [va-during-2001] beta-Carotene 15,15'-Dioxygenase activity in human tissues and cells: evidence of an iron dependency (2001). https://pubmed.ncbi.nlm.nih.gov/12031257/ DOI: 10.1016/S0955-2863(01)00184-X
- tissue_or_cell_type
- Small-intestinal mucosa and Caco-2 TC7 cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 187–200
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human small-intestinal mucosa and Caco-2 TC7 cells; desferrioxamine and iron addition. · source_derived_draft · unverified_draft
### va-iron-chelation-cleavage Desferrioxamine reduced beta-carotene-cleaving activity in human intestinal mucosa and TC7 cells. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Sequestering iron limited conversion of provitamin A to retinal. organism: Homo sapiens tissue_or_cell_type: Small-intestinal mucosa and Caco-2 TC7 cells experimental_model: Human small-intestinal mucosa and Caco-2 TC7 cells; desferrioxamine and iron addition. limitations: Drug-induced chelation; BCO1 protein abundance and human dietary deficiency were not directly established. exposure: Increasing desferrioxamine concentrations. outcome: Desferrioxamine reduced beta-carotene-cleaving activity in human intestinal mucosa and TC7 cells. evidence_location: Abstract cross_nutrient: Iron availability supports provitamin A cleavage in this in vitro model. [va-during-2001] beta-Carotene 15,15'-Dioxygenase activity in human tissues and cells: evidence of an iron dependency (2001). https://pubmed.ncbi.nlm.nih.gov/12031257/ DOI: 10.1016/S0955-2863(01)00184-X
Complete structured claim and evidence
Where it participates (unsigned role)
Adding iron reversed desferrioxamine inhibition of carotenoid cleavage in TC7 cells.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Direct cellular iron-to-vitamin-A precursor interaction.
- evidence_location
- Abstract
- experimental_model
- Human small-intestinal mucosa and Caco-2 TC7 cells; desferrioxamine and iron addition.
- exposure
- Iron added during the chelation experiment.
- limitations
- Accessible source does not resolve the added salt/speciation; not a clinical repletion result.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Homo sapiens
- outcome
- Adding iron reversed desferrioxamine inhibition of carotenoid cleavage in TC7 cells.
- plain_language
- Iron restored the inhibited retinal-producing reaction.
- primary_references
- [va-during-2001] beta-Carotene 15,15'-Dioxygenase activity in human tissues and cells: evidence of an iron dependency (2001). https://pubmed.ncbi.nlm.nih.gov/12031257/ DOI: 10.1016/S0955-2863(01)00184-X
- tissue_or_cell_type
- Caco-2 TC7 cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 202–215
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human small-intestinal mucosa and Caco-2 TC7 cells; desferrioxamine and iron addition. · source_derived_draft · unverified_draft
### va-iron-rescue-cleavage Adding iron reversed desferrioxamine inhibition of carotenoid cleavage in TC7 cells. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Iron restored the inhibited retinal-producing reaction. organism: Homo sapiens tissue_or_cell_type: Caco-2 TC7 cells experimental_model: Human small-intestinal mucosa and Caco-2 TC7 cells; desferrioxamine and iron addition. limitations: Accessible source does not resolve the added salt/speciation; not a clinical repletion result. exposure: Iron added during the chelation experiment. outcome: Adding iron reversed desferrioxamine inhibition of carotenoid cleavage in TC7 cells. evidence_location: Abstract cross_nutrient: Direct cellular iron-to-vitamin-A precursor interaction. [va-during-2001] beta-Carotene 15,15'-Dioxygenase activity in human tissues and cells: evidence of an iron dependency (2001). https://pubmed.ncbi.nlm.nih.gov/12031257/ DOI: 10.1016/S0955-2863(01)00184-X
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.