Component
Cysteamine-cysteine mixed-disulfide efflux
Cysteamine-cysteine mixed-disulfide efflux. Experimental scope belongs to the associated record.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The cysteamine-cysteine mixed disulfide left treated cystinotic fibroblasts, contributing to depletion of accumulated cellular cystine.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_location
- Primary indexed abstract, including metabolite-tracing conclusion.
- experimental_model
- Radiolabeled cystine metabolite-tracing experiment in cultured patient fibroblasts
- exposure
- Pantethine or cystamine treatment; specific concentration not retrieved from the primary abstract.
- limitations
- Disease-derived cultured cells; no molecular exporter is assigned without evidence. Formation and efflux of a mixed disulfide do not prove that pantothenate alone treats cystinosis.
- nutrient_topic
- Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
- organism
- Homo sapiens
- plain_language
- Export of the new disulfide helped remove the stored cystine.
- primary_references
- [b5-clin-butler1984] Pantethine and cystamine deplete cystine from cystinotic fibroblasts via efflux of cysteamine-cysteine mixed disulfide. (1984). https://pubmed.ncbi.nlm.nih.gov/6746900/ DOI: 10.1172/jci111436
- tissue_or_cell_type
- Cystinotic fibroblast lysosomes and extracellular medium
Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1509–1521
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Radiolabeled cystine metabolite-tracing experiment in cultured patient fibroblasts · source_derived_draft · unverified_draft
### b5-clin-mixed-disulfide-efflux The cysteamine-cysteine mixed disulfide left treated cystinotic fibroblasts, contributing to depletion of accumulated cellular cystine. Condition category: normal nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Export of the new disulfide helped remove the stored cystine. organism: Homo sapiens tissue_or_cell_type: Cystinotic fibroblast lysosomes and extracellular medium experimental_model: Radiolabeled cystine metabolite-tracing experiment in cultured patient fibroblasts limitations: Disease-derived cultured cells; no molecular exporter is assigned without evidence. Formation and efflux of a mixed disulfide do not prove that pantothenate alone treats cystinosis. exposure: Pantethine or cystamine treatment; specific concentration not retrieved from the primary abstract. cross_nutrient: false evidence_location: Primary indexed abstract, including metabolite-tracing conclusion. [b5-clin-butler1984] Pantethine and cystamine deplete cystine from cystinotic fibroblasts via efflux of cysteamine-cysteine mixed disulfide. (1984). https://pubmed.ncbi.nlm.nih.gov/6746900/ DOI: 10.1172/jci111436
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.